@article{article_103962, title={Effect of levetiracetam on hepatic fibrosis in diabetic rats}, journal={İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi}, volume={1}, pages={87–93}, year={2015}, DOI={10.5606/fng.btd.2015.016}, author={Uyanıkgil, Yiğit and Akman, Tülay and Çavuşoğlu, İbrahim and Kısmalı, Erkan and Taşkıran, Dilek and Erbaş, Oytun}, keywords={Diabetes mellitus, levetirasetam, oksidatif stres, gerçek zamanlı elastografi}, abstract={<p> <strong>Objectives: </strong> In our study we investigated the possible effects of levetiracetam (LEV) on hepatic fibrosis in streptozotocin (STZ) induced diabetic rats with histopathology, real-time elastography imaging technique. We also aimed to investigate the effects of LEV on oxidative stress markers. </p> <p> <strong>Materials and methods: </strong> Diabetes was induced by intraperitoneal (i.p.) single dose injection of STZ (60 mg/kg). Twenty-one rats were randomly divided into three groups; control group, STZ group treated with 1 mL/kg/day saline (STZ+SP), and STZ group treated with 600 mg/kg/day LEV was administrated by i.p. for four weeks. All rats underwent a real-time elastography (strain-elasticity %). The liver sections are examined by histopathologically (liver fibrosis score). In addition, malondialdehyde, total antioxidant capacity, and glutathione levels were measured in plasma. </p> <p> <strong>Results: </strong> Treatment with LEV significantly decreased liver fibrosis score and increased strain measurement % on the real-time elastography in diabetic rats. In addition, treatment with LEV significantly increased total antioxidant capacity, glutathione and malondialdehyde levels decreased in plasma of diabetic rats. </p> <p> <strong>Conclusion: </strong> Levetiracetam has potential as a treatment for diabetic liver injury and hepatic fibrosis and can be a good candidate among new treatment options. In addition, real-time elastography is reliable imaging non-invasive technique for detecting hepatic fibrosis. </p> <p> <strong>Keywords: </strong> Diabetes mellitus; levetiracetam; oxidative stress; real-time elastography. </p>}, number={2}, publisher={Demiroğlu Bilim Üniversitesi}