@article{article_1046475, title={Pepsinogen identification in the middle ear fluid of children with otitis media with effusion}, journal={The Turkish Journal of Ear Nose and Throat}, volume={26}, pages={73–78}, year={2016}, author={Buyruk, Aytuğ and Osma, Üstün and Yılmaz, Mustafa Deniz and Eyigör, Hülya}, keywords={Gastro-özofageal reflü, efüzyonlu otitis media, pepsin, pepsinojen}, abstract={Objectives: This study aims to investigate the presence and concentration of pepsin/pepsinogen in middle ear fluid and to discuss the potential mechanisms involved in the pathogenesis of this condition. Patients and Methods: A total of 33 children 21 boys, 12 girls; mean age 5.7±2.4 years; range 3 to 13 years diagnosed with otitis media with effusion and scheduled for operation were enrolled into the study. Fluids aspirated from the middle ear were assessed for the presence of pepsinogen and albumin and blood samples were drawn simultaneously for comparison. Results: Mean pepsinogen concentration was statistically significantly higher in middle ear fluids compared with serum samples 262.4 ng/mL [range: 211.7 ng/mL - 301.1 ng/mL] versus 102.6 ng/mL [range: 80.7 ng/mL - 134.5 ng/mL], respectively p <0.001 . On the other hand, mean albumin concentration was significantly lower 1.1 g/dL [range: 0.01 g/dL - 9.5 g/dL] versus 5.8 g/dL [range: 0.9 - 9.5 g/dL], respectively p <0.001 . The highest pepsinogen concentration was detected in patients with purulent effusion 275.3 ng/mL . Conclusion: Our findings support the theory of gastro-esophageal reflux related pepsinogen transition to the middle ear and indicate that pepsinogen may a reliable biochemical marker for the assessment of gastro-esophageal reflux.}, number={2}, publisher={İstanbul Üniversitesi}