@article{article_1047174, title={Multi-Drug Resistance-1 [MDR1, P-gp, ABCB1] Gene Polymorphism in Patients with Abdominal Aortic Aneurysm and Their Family Members}, journal={Akdeniz Tıp Dergisi}, volume={4}, pages={233–238}, year={2018}, author={Yağmur, Bayram and Tekin, Ali İhsan}, keywords={Abdominal aort anevrizması, MDR1 gen polimorfizmi}, abstract={Objective: The aim of this study was to investigate the relationship between the 3435C>T polymorphism in the multi-drug resistance-1 gene [MDR1, P-gp, ABCB1] and the development of abdominal aortic aneurysm AAA .Material and Methods: This study included 75 patients with AAA Group I , 75 individuals who were first-degree relatives of these patients but did not have AAA diagnosis Group II , and 75 healthy volunteers whose abdominal aortic diameters were in the normal range Group III . Genomic DNAs of these individuals were obtained from the peripheral blood. The MDR1:c.3435C>T polymorphism [CC Wild Type , CT Heterozygous and TT Homozygous genotypes] was investigated by using the real-time polymerase chain reaction technique real-time PCR .Results: MDR1 TT genotype was significantly more frequent in Groups I and II compared to Group III 33.3% and 38.6% vs. 8%, respectively, p}, number={3}, publisher={Akdeniz Üniversitesi}