TY  - JOUR
T1  - Preservation of C-Peptide Levels in Children with New-Onset Type 1 Diabetes: A Comparison Based on Body Mass Index
TT  - Yeni Tanı Tip 1 Diyabetli Çocuklarda Korunmuş C-Peptid Düzeyleri: Vücut Kütle İndeksine Dayalı Bir Karşılaştırma
AU  - Karagüzel, Gülay
AU  - Cimbek, Emine Ayça
AU  - Öztürk, Mehmet Aykut
PY  - 2022
DA  - April
Y2  - 2022
DO  - 10.25048/tudod.1059061
JF  - Turkish Journal of Diabetes and Obesity
JO  - Turk J Diab Obes
PB  - Zonguldak Bülent Ecevit Üniversitesi
WT  - DergiPark
SN  - 2587-0335
SP  - 32
EP  - 38
VL  - 6
IS  - 1
LA  - en
AB  - Aim: The contemporaneous increase in type 1 diabetes (T1D) and obesity prevalence in children has led to conflicting reports regardingthe effects of weight excess on beta-cell function and clinical manifestation of T1D. We aimed to analyze the association between bodymass index (BMI) and beta-cell function in a large cohort of new-onset T1D youth.Material and Methods: This study included 204 consecutive children with T1D aged 1-18 years. We retrospectively reviewed themedical data. The preservation of C-peptide was defined as a C-peptide level ≥0.6 ng/mL. Comparisons of variables between groupswere made using appropriate statistical procedures.Results: Eighteen percent of children were overweight or obese. Overweight/obesity was associated with significantly higher C-peptidelevels at onset [0.57 (0.05-2.99) vs 0.41 (0.05-2.58) ng/ml, p=0.01]. Preservation of C-peptide levels was observed in 67% of patients.Patients with preserved C-peptide levels were older at onset [10.4 (1.9-16.5) vs 7.5 (1.1-17.3) yr, p
KW  - Type 1 diabetes
KW  - Obesity
KW  - Overweight
KW  - C-peptide
KW  - Children
N2  - Amaç: Çocuklarda tip 1 diyabet (T1D) ve obezite prevalansındaki eşzamanlı artış, aşırı kilonun beta hücre fonksiyonu ve T1D'nin ortayaçıkışı üzerine etkilerine dair çelişkili raporlara yol açmıştır. Yeni tanı T1D’li çocuklardan oluşan geniş bir kohortta vücut kütle indeksi(VKİ) ile beta hücre fonksiyonu arasındaki ilişkiyi incelemeyi amaçladık.Gereç ve Yöntemler: Bu çalışmaya 1-18 yaş arası T1D tanılı 204 ardışık çocuk dahil edildi. Tıbbi verileri geriye dönük olarak inceledik.Korunmuş C-peptid düzeyi ≥0.6 ng/mL olarak tanımlandı. Değişkenlerin gruplar arası karşılaştırmaları uygun istatistiksel prosedürlerkullanılarak yapıldı.Bulgular: Çocukların %18'i aşırı kilolu veya obezdi. Fazla kilo/obezite, tanı anında önemli ölçüde daha yüksek C-peptid seviyeleri ileilişkiliydi [0.57 (0.05-2.99)'ye karşı 0.41 (0.05-2.58) ng/ml, p=0.01]. Hastaların %67'sinde C-peptid düzeylerinin korunduğu gözlendi.Korunmuş C-peptid düzeyi grubundaki hastalar tanı anında daha ileri yaştaydı [10.4 (1.9-16.5)'e karşı 7.5 (1.1-17.3) yıl, p
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UR  - https://doi.org/10.25048/tudod.1059061
L1  - https://dergipark.org.tr/tr/download/article-file/2196974
ER  -