TY  - JOUR
T1  - Deneysel Akut Pankreatit Oluşturulan Ratlarda Lipit Profil Üzerine Timokinonun Etkileri
TT  - Effects of Thymoquinone on Lipid Profile in Rats with Experimentally Acute Pancreatitis
AU  - Uluışık, Deniz
AU  - Kanaç, Sevim
AU  - Keskin, Ercan
PY  - 2022
DA  - May
Y2  - 2022
DO  - 10.31196/huvfd.1066860
JF  - Harran University Journal of the Faculty of Veterinary Medicine
JO  - Harran Univ Vet Fak Derg
PB  - Harran Üniversitesi
WT  - DergiPark
SN  - 2146-7188
SP  - 58
EP  - 65
VL  - 11
IS  - 1
LA  - tr
AB  - Çalışmada serulein ile akut pankreatit oluşturulan ratlarda timokinonun lipit profil üzerine olası etkilerinin belirlenmesi amaçlanmıştır. Çalışma süresi olan 9 gün boyunca kontrol grubuna (K) herhangi bir uygulama yapılmadı. Timokinon grubundaki (TQ) hayvanlara 9 gün süre ile günde 20 mg/kg timokinon intraperitoneal olarak verilirken, akut pankreatit grubundaki (AP) hayvanlarda araştırmanın 7. gününde 50 μg/kg ve 2 saat sonra 25 μg/kg seruleinin intraperitoneal olarak uygulanmasıyla akut pankreatit oluşturuldu. Akut pankreatit+timokinon grubunda ise (AP+TQ) günde 20 mg/kg olmak üzere 9 gün süre ile intraperitoneal olarak timokinon verilen hayvanlarda araştırmanın 7. gününde timokinon uygulamasından 2 saat sonra 50 μg/kg ve bundan 2 saat sonra 25 μg/kg seruleinin intraperitoneal olarak uygulanmasıyla akut pankreatit oluşturuldu. Bütün hayvanlardan alınan kan örneklerinde Lipaz, Amilaz, Trigliserit, Total Kolesterol, Düşük dansiteli lipoprotein (LDL-kolesterol) ve Yüksek dansiteli lipoprotein (HDL-kolesterol) düzeyleri belirlendi. Deneysel akut pankreatit oluşturulan ratlarda amilaz ve lipaz düzeyleri kontrol grubuna göre anlamlı olarak yüksek olduğu belirlendi (p<0.05). Akut pankreatit oluşturulan grupta yüksek olan bu enzim düzeylerinin timokinon uygulanan akut pankreatitli ratlarda önemli oranda baskılandığı belirlendi (p<0.05). Çalışmada serulein ile oluşturulan deneysel akut pankreatite bağlı olarak plazma trigliserit ve total kolesterol düzeylerinin kontrol grubuna göre önemli oranda yüksek olduğu belirlendi (p<0.05). Akut pankreatitli ratlarda LDL-kolesterol düzeyi kontrol grubuna göre anlamlı oranda yüksek bulunurken (p<0.05), HDL-kolesterol düzeyi ise anlamlı oranda düşüktü (p<0.05). Timokinon uygulanan akut pankreatitli ratların total kolesterol ve LDL-kolesterol düzeylerinin akut pankreatitli gruba göre anlamlı oranda düşük olduğu belirlendi (p<0.05). Sonuç olarak, plazma lipit parametreleri ve bazı enzim düzeylerindeki farklılıklar dikkate alındığında timokinonun akut pankreatit üzerine olumlu etkileri olduğu kanaatine varıldı.
KW  - Serulein
KW  - Timokinon
KW  - Lipit Profil
KW  - Rat
N2  - This study aimed to determine the possible effects of thymoquinone on lipid profile in rats with cerulein-induced acute pancreatitis. No application was made to the control group (K) during the study period of nine days. The thymoquinone group (TQ) animals were administered 20 mg/kg of thymoquinone daily for nine days. In the acute pancreatitis group (AP), acute pancreatitis was induced by intraperitoneal cerulein administration of 50 μg/kg and 2 hours later, 25 μg/kg on the seventh day of the study. Animals in the acute pancreatitis+thymoquinone group (AP+TQ) were intraperitoneally administered 20 mg/kg of thymoquinone daily for nine days. On the seventh day of the study, acute pancreatitis was induced by intraperitoneal administration of 50 μg/kg and 2 hours later 25 μg/kg of cerulein after 2 hours from thymoquinone administration. In blood samples taken from all animals, Lipase, Amylase, Triglyceride, Total Cholesterol, low-density lipoprotein (LDL-cholesterol), and high-density lipoprotein (HDL-cholesterol) levels were determined. The amylase and lipase levels of rats with acute experimental pancreatitis were significantly higher than the control group (p<0.05). It was determined that these enzyme levels, which were high in the acute pancreatitis group, were significantly suppressed in rats with acute pancreatitis treated with thymoquinone (p<0.05). The increase in plasma triglyceride and total cholesterol levels due to acute experimental pancreatitis induced with cerulein was significant compared to the control group (p<0.05). LDL-cholesterol level of rats with acute pancreatitis was found to be significantly higher than the control group (p<0.05), while HDL-cholesterol level was significantly lower (p<0.05). The total cholesterol and LDL-cholesterol levels of rats with acute pancreatitis treated with thymoquinone were significantly lower than those of the acute pancreatitis group (p<0.05). In conclusion, in light of differences in plasma lipid parameters and some enzyme levels, it was considered that thymoquinone has positive effects on acute pancreatitis.
CR  - Abdel-Daim MM, Abo El-Ela FI, Alshahrani FK, Bin-Jumah M, Al-Zharani M, Almutairi B, Alyousif MS, Bungau S, Aleya L, Alkahtani S, 2020: Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats. Environ Sci Pollut Res Int, 27 (30), 37709-37717. doi: 10.1007/s11356-020-09516-3.
CR  - Ahmad S, Beg ZH, 2013: Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chem, 138 (2-3), 1116-1124.
CR  - Al-Naqeep G, Al-Zubairi AS, Ismail M, Amom ZH, Esa NM, 2011: Antiatherogenic potential of Nigella sativa seeds and oil in diet-induced hypercholesterolemia in rabbits. Evid Based Complement Alternat Med, 2011, 213628. doi: 10.1093/ecam/neq071.
CR  - Al-Naqeep G, Ismail M, Allaudin Z, 2009: Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells. Lifestyle Genomics, 2 (4-5), 163-172.
CR  - Andican G, Gelisgen R, Unal E, Tortum OB, Dervisoglu S, Karahasanoglu T, Burçak G, 2005: Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis. World J Gastroenterol, 11 (15), 2340-2345. doi: 10.3748/wjg.v11.i15.2340.
CR  - Asgary S, Ghannadi A, Dashti G, Helalat A, Sahebkar A, Najafi S, 2013: Nigella sativa L. improves lipid profile and prevents atherosclerosis: Evidence from an experimental study on hypercholesterolemic rabbits. J Funct Foods, 5 (1), 228-234.
CR  - Ashraf SS, Rao MV, Kaneez FS, Qadri S, Al-Marzouqi AH, Chandranath IS, Adem A, 2011: Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress. J Chromatogr Sci, 49 (4), 321-326. doi: 10.1093/chrsci/49.4.321.
CR  - Badary OA, Abdel-Naim AB, Abdel-Wahab MH, Hamada FM, 2000: The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology, 143 (3), 219-226.
CR  - Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH, 2003: Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol, 26 (2), 87-98. doi: 10.1081/dct-120020404.
CR  - Baggio G, Manzato E, Gabelli C, Fellin R, Martini S, Enzi GB, Verlato F, Baiocchi M, Sprecher D, Kashyap M, 1986: Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients. J Clin Invest, 77 (2), 520-527.
CR  - Bamosa A, Ali BA, Al-Hawsawi ZA, 2002: The effect of thymoquinone on blood lipids in rats. Indian J Physiol Pharmacol, 46 (2), 195-201.
Banks PA, Freeman ML, Gastroenterology PPCotACo, 2006: Practice guidelines in acute pancreatitis. Official Journal of the American College of Gastroenterology ACG, 101 (10), 2379-400.
CR  - Bansod S, Chilvery S, Saifi MA, Das TJ, Tag H, Godugu C, 2021: Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model. Environ Toxicol, 36 (4), 530-539.
CR  - Bhatti IU, Rehman FU, Khan MA, Marwat SK, 2009: Effect of prophetic medicine Kalonji (Nigella sativa L.) on lipid profile of human beings: an in vivo approach.  World Appl Sci J, 6(8), 1053-1057.
CR  - Bugdaci MS, Sokmen M, Zuhur SS, Altuntas Y, 2011: Lipid profile changes and importance of low serum α-lipoprotein fraction (high-density lipoprotein) in cases with acute pancreatitis. Pancreas, 40 (8), 1241-1244.
CR  - Chen X, Wu Y, Liu L, Su Y, Peng Y, Jiang L, Liu X, Huang D, 2010: Relationship between high density lipoprotein antioxidant activity and carotid arterial intima-media thickness in patients with essential hypertension. Clin Exp Hypertens, 32 (1), 13-20.
CR  - Clemens DL, Mahan KJ, 2010: Alcoholic pancreatitis: Lessons from the liver. World J Gastroenterol: WJG, 16 (11), 1314-1320.
CR  - Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN, 2018: American Gastroenterological Association Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis. Gastroenterology, 154 (4), 1096-1101. doi: 10.1053/j.gastro.2018.01.032.
CR  - Czakó L, Takács T, Varga IS, Tiszlavicz L, Hegyi P, Matkovics B, Lonovics J, 2000: Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis. Int J Pancreatol, 27 (3), 209-216.
CR  - Darakhshan S, Pour AB, Colagar AH, Sisakhtnezhad S, 2015: Thymoquinone and its therapeutic potentials. Pharmacol Res, 95, 138-158.
CR  - Dominguez-Munoz J, Malfertheiner P, Ditschuneit H, Blanco-Chavez J, UhL W, Bückler M, Ditschuneit H, 1991: Hyperlipidemia in acute pancreatitis. Int J Pancreatol, 10 (3), 261-267.
CR  - Dziurkowska-Marek A, Marek TA, Nowak A, Kacperek-Hartleb T, Sierka E, Nowakowska-Dulawa E, 2004: The dynamics of the oxidant-antioxidant balance in the early phase of human acute biliary pancreatitis. Pancreatology, 4 (3-4), 215-222.
CR  - El-Dakhakhny M, Mady NI, Halim MA, 2000: Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung, 50 (9), 832-836.
CR  - Emancipator K, Csako G, Elin R, 1992: In vitro inactivation of bacterial endotoxin by human lipoproteins and apolipoproteins. Infect Immun, 60 (2), 596-601.
CR  - Ettinger WH, Varma VK, Sorci-Thomas M, Parks JS, Sigmon RC, Smith TK, Verdery RB, 1994: Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. Arterioscler Thromb Vasc Biol, 14 (1), 8-13.
CR  - Farzaneh E, Nia FR, Mehrtash M, Mirmoeini FS, Jalilvand M, 2014: The effects of 8-week Nigella sativa supplementation and aerobic training on lipid profile and VO2 max in sedentary overweight females. Int J Prev Med, 5 (2), 210.
CR  - Flegel W, Baumstark M, Weinstock C, Berg A, Northoff H, 1993: Prevention of endotoxin-induced monokine release by human low-and high-density lipoproteins and by apolipoprotein AI. Infect Immun, 61 (12), 5140-5146.
CR  - Fouad A, Jresat I, 2015: Thymoquinone therapy abrogates toxic effect of cadmium on rat testes. Andrologia, 47 (4), 417-426.
CR  - Gholamnezhad Z, Havakhah S, Boskabady MH, 2016: Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. J Ethnopharmacol, 190, 372-386.
CR  - Güllü EB, Gülcan A, 2013: Timokinon: Nigella Sativa’nın biyoaktif komponenti. Kocatepe Vet Derg, 6 (1), 51-61.
CR  - Ibrahim RM, Hamdan NS, Mahmud R, Imam MU, Saini SM, Abd Rashid SN, Abd Ghafar SA, Ab Latiff L, Ismail M, 2014: A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women. J Transl Med, 12 (1), 1-7.
CR  - Ikeı S, Ogawa M, Yamaguchı Y, 1998: Blood concentrations of polymorphonuclear leucocyte elastase and interleukin‐6 are indicators for the occurrence of multiple organ failures at the early stage of acute pancreatitis. J Gastroenterol Hepatol, 13 (12), 1274-1283.
CR  - Ismail OZ, Bhayana V, 2017: Lipase or amylase for the diagnosis of acute pancreatitis? Clin Biochem, 50 (18), 1275-1280.
CR  - Kocyigit Y, Atamer Y, Uysal E, 2009: The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. Saudi Med J, 30 (7), 893-896.
CR  - Kumar MM, Tamizhselvi R, 2020: Protective effect of diallyl disulfide against cerulein-induced acute pancreatitis and associated lung injury in mice. Int Immunopharmacol, 80, 106136. doi: 10.1016/j.intimp.2019.106136.
CR  - Lam PP, Cosen Binker LI, Lugea A, Pandol SJ, Gaisano HY, 2007: Alcohol redirects CCK‐mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis. Traffic, 8 (5), 605-617.
CR  - Lee JH, Park JH, Lee SH, Kim JR, Cho KH, 2010: Elevated HDL2-paraoxonase and reduced CETP activity are associated with a dramatically lower ratio of LDL-cholesterol/total cholesterol in a hypercholesterolemic and hypertriglyceridemic patient. Int J Mol Med, 25 (6), 945-951.
CR  - Leema G, Tamizhselvi R, 2018: Protective Effect of Scopoletin Against Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice. Pancreas, 47 (5), 577-585. doi: 10.1097/MPA.0000000000001034.
CR  - Leung PS, Chan YC, 2009: Role of oxidative stress in pancreatic inflammation. Antioxid Redox Sign, 11 (1), 135-166.
CR  - Liao W, Rudling M, Angelin B, 1999: Endotoxin suppresses mouse hepatic low‐density lipoprotein–receptor expression via a pathway independent of the toll‐like receptor 4. Hepatology, 30 (5), 1252-1256.
CR  - Nader MA, El-Agamy DS, Suddek GM, 2010: Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res, 33 (4), 637-643.
CR  - Nagi MN, Almakki HA, Sayed-Ahmed MM, Al-Bekairi AM, 2010: Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver. Food Chem Toxicol, 48 (8-9), 2361-2365. doi: 10.1016/j.fct.2010.05.072.
CR  - Najmi A, Nasiruddin M, Khan R, Haque SF, 2012: Therapeutic effect of Nigella sativa in patients of poor glycemic control. Asian J Pharm Clin Res, 5 (3), 224-228.
CR  - Najmi A, Nasiruddin M, Khan RA, Haque SF, 2008: Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev Ctries, 28 (1), 11-14.
CR  - Negi N, Mokta J, Sharma B, Sharma R, Jhobta A, Bodh V, Ranjan A, 2018: Clinical Profile and Outcome of Acute Pancreatitis: A Hospital-Based Prospective Observational Study in Subhimalayan State. J Assoc Phys India, 66, 22-24.
CR  - Nonaka A, Manabe T, Kyogoku T, Tamura K, Tobe T, 1990: Changes in lipid peroxide and oxygen radical scavengers in cerulein-induced acute pancreatitis. Digestion, 47 (3), 130-137.
CR  - Nonaka A, Manabe T, Tamura K, Asano N, Imanishi K, Tobe T, 1989: Changes of xanthine oxidase, lipid peroxide and superoxide dismutase in mouse acute pancreatitis. Digestion, 43 (1-2), 41-46.
CR  - Okura Y, Hayashi K, Shingu T, Kajiyama G, Nakashima Y, Saku K, 2004: Diagnostic evaluation of acute pancreatitis in two patients with hypertriglyceridemia. World J Gastroenterol: WJG, 10 (24), 3691.
CR  - Pădureanu V, Florescu DN, Padureanu R, Ghenea AE, Gheonea DI, Oancea CN, 2022: Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review). Exp Ther Med, 23. doi: 10.3892/etm.2022.11120.
CR  - Pakala R, Stabile E, Jang GJ, Clavijo L, Waksman R, 2005: Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis. J Cardiovasc Pharmacol, 46 (4), 481-486.
CR  - Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP, 2015: Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation. Am J Pathol, 185 (3), 808-819.
CR  - Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, Wu CS, Hung CF, Hwang TL, Tsai YH, 2015: Serum levels of apolipoprotein AI and high-density lipoprotein can predict organ failure in acute pancreatitis. Crit Care, 19 (1), 1-9.
CR  - Podrez EA, 2010: Anti‐oxidant properties of high‐density lipoprotein and atherosclerosis. Clin Exp Pharmacol Physiol, 37 (7), 719-725.
CR  - Qidwai W, Ashfaq T, 2014: Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes. Antiinflamm Antiallergy Agents Med Chem, 13 (1), 3-8. doi: 10.2174/18715230113129990020.
CR  - Que RS, Cao LP, Ding GP, Hu JA, Mao KJ, Wang GF, 2010: Correlation of nitric oxide and other free radicals with the severity of acute pancreatitis and complicated systemic inflammatory response syndrome. Pancreas, 39 (4), 536-540. doi: 10.1097/MPA.0b013e3181c0e199.
CR  - Radad K, Moldzio R, Taha M, Rausch WD, 2009: Thymoquinone protects dopaminergic neurons against MPP+ and rotenone. Phytother Res, 23 (5), 696-700. doi: 10.1002/ptr.2708.
CR  - Ragheb A, Elbarbry F, Prasad K, Mohamed A, Ahmed MS, Shoker A, 2008: Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone. Int J Angiol, 17 (4), 186-192. doi: 10.1055/s-0031-1278307.
CR  - Roberts SE, Morrison-Rees S, John A, Williams JG, Brown TH, Samuel DG, 2017: The incidence and aetiology of acute pancreatitis across Europe. Pancreatology, 17(2), 155-165.
CR  - Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A, 2012: Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Med Arch, 66 (3), 198-200.
CR  - Schmidt J, Lewandrowski K, Fernandez-del Castillo C, Mandavilli U, Compton C, Warshaw A, Rattner D, 1992: Histopathologic correlates of serum amylase activity in acute experimental pancreatitis. Dig Dis Sci, 37 (9), 1426-1433.
CR  - Schoenberg MH, Birk D, Beger HG, 1995: Oxidative stress in acute and chronic pancreatitis. Am J Clin Nutr, 62 (6 Suppl), 1306S-1314S. doi: 10.1093/ajcn/62.6.1306S.
CR  - Shabana A, El-Menyar A, Asim M, Al-Azzeh H, Al Thani H, 2013: Cardiovascular benefits of black cumin (Nigella sativa). Cardiovasc Toxicol, 13 (1), 9-21.
CR  - Song R, Yu D, Park J, 2016: Changes in gene expression of tumor necrosis factor alpha and interleukin 6 in a canine model of caerulein-induced pancreatitis. Can J Vet Res, 80 (3), 236-241.
CR  - Sweiry JH, Mann GE, 1996: Role of oxidative stress in the pathogenesis of acute pancreatitis. Scand J Gastroenterol, 219, 10‑15. doi: 10.3109/00365529609104992.
CR  - Tribble DL, Chu BM, Gong EL, van Venrooij F, Nichols A, 1995: HDL antioxidant effects as assessed using a nonexchangeable probe to monitor particle-specific peroxidative stress in LDL-HDL mixtures. J Lipid Res, 36 (12), 2580-2589.
CR  - Tsai K, Wang S, Chen T, Kong CW, Chang FY, Lee SD, Lu FJ, 1998: Oxidative stress: an important phenomenon with pathogenetic significance in the progression of acute pancreatitis. Gut, 42 (6), 850-855.
CR  - Tvarijonaviciute A, García-Martínez JD, Caldin M, Martínez-Subiela S, Tecles F, Pastor J, Ceron JJ, 2015: Serum paraoxonase 1 (PON1) activity in acute pancreatitis of dogs. J Small Anim Pract, 56 (1), 67-71. doi: 10.1111/jsap.12297.
CR  - Unal E, Uzun H, Kusaslan R, Dogan M, Genc H, Gunes P, Titiz I, 2005: Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity and lipid profile in experimental acute pancreatitis. Pancreas, 31 (1), 84-87.
CR  - Van DIjk SM, Hallensleben NDL, van Santvoort HC, Fockens P, van Goor H, Bruno MJ, Besselink MG, ; Dutch Pancreatitis Study Group, 2017: Acute pancreatitis: recent advances through randomised trials. Gut, 66 (11), 2024-2032. doi: 10.1136/gutjnl-2016-313595.
CR  - Vardar D, Mollahaliloğlu S, Öztaş D, 2018: Examining the effects of phytochemicals used in phytotherapy on public health. J Health Sci Med, 1 (4), 99-105.
CR  - Velusamy RK, Tamizhselvi R, 2018: Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice. J Pharm Pharmacol, 70 (9), 1188-1199. doi: 10.1111/jphp.12946.
CR  - Wan J, He W, Zhu Y, Zhu Y, Zeng H, Liu P, Xia L, Lu N, 2017: Stratified analysis and clinical significance of elevated serum triglyceride levels in early acute pancreatitis: a retrospective study. Lipids Health Dis, 16 (1), 1-7.
CR  - Wang GJ, Gao CF, Wei D, Wang C, Ding SQ, 2009a: Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol: WJG, 15 (12), 1427-1430.
CR  - Wang YJ, Sun JB, Li F, Zhang SW, 2006: Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats. World J Gastroenterol: WJG, 12 (18), 2908-2913.
CR  - Wang Y, Sternfeld L, Yang F, Rodriguez JA, Ross C, Hayden MR, Carriere F, Liu G, Hofer W, Schulz I, 2009b: Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells. Gut, 58 (3), 422-430.
CR  - Weidner G, Connor SL, Chesney MA, Burns JW, Connor WE, Matarazzo JD, Mendell NR, 1991: Sex differences in high density lipoprotein cholesterol among low-level alcohol consumers. Circulation, 83 (1), 176-180.
CR  - Werlang ME, Lewis MD, Bartel MJ, 2017: Tumor Necrosis Factor Alpha Inhibitor-Induced Acute Pancreatitis. ACG Case Rep J, 4 (1), e103. doi: 10.14309/crj.2017.103.
CR  - Woo CC, Kumar AP, Sethi G, Tan KHB, 2012: Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol, 83 (4), 443-451.
CR  - Yvan-Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, Sparrow CP, Taggart AK, Tall AR, 2010: Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. Arterioscler Thromb Vasc Biol, 30 (7), 1430-1438.
CR  - Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M, 2002: Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol, 79 (1), 23-26.
CR  - Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A, 2009: Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res, 50 (1), 3-21.
CR  - Zhang X, Zhu C, Wu D, Jiang X, 2010: Possible role of toll-like receptor 4 in acute pancreatitis. Pancreas, 39 (6), 819-824.
UR  - https://doi.org/10.31196/huvfd.1066860
L1  - http://dergipark.org.tr/tr/download/article-file/2227494
ER  -