@article{article_1071761, title={Potential effects of punicalagin on New Zealand White rabbits exposed to bisphenol A}, journal={Kocatepe Veterinary Journal}, volume={15}, pages={259–268}, year={2022}, DOI={10.30607/kvj.1071761}, author={Gülay, Özlem Yildiz and Candan, Gülşah and Gülay, Mehmet Şükrü}, keywords={Antioksidanlar, Kolesterol, Oksidan-Antioksidan enzimler, Polifenoller, Toksikasyon}, abstract={The possible effects of punicalagin on some oxidant-antioxidant enzymes and biochemical parameters in <br />bisphenol A (BPA)-treated rabbits were investigated. Animals were randomly divided into 4 groups, each <br />containing 6 rabbits: Control (C; corn oil and distilled water), BPA (BPA; 20 mg/kg BPA in corn oil and distilled <br />water), the punicalagin (PUN; corn oil and 2 mg/kg punicalagin in distilled water), and BPA-punicalagin (B+P; 20 <br />mg/kg BPA in corn oil and 2 mg/kg PUN in distilled water) groups. Daily treatments continued for 9 weeks and <br />doses were adjusted according to body weights measured for each week. At the end of the study, hematological, <br />biochemical, and oxidant-antioxidant parameters were measured from blood and tissue samples. The difference <br />in the levels of plasma bilirubin, albumin, total plasma protein, Mg, P, Ca, Na, K, and levels of glutathione <br />peroxidase in plasma, liver, and kidney were non-significant (p>0.1). However, oral BPA administration adversely <br />affected serum cholesterol, LDL, HDL, amylase, lipase, CRP, and GGT concentrations. Likewise, <br />malondialdehyde, catalase, and superoxide dismutase levels in the kidney and liver were also negatively altered by <br />BPA (p<0.05). Significant improvements in these parameters were apparent in the B+P group. The data <br />generated here showed that punicalagin possessed a beneficial impact on potentially reducing the possible toxic <br />effects of BPA in rabbits. }, number={3}, publisher={Afyon Kocatepe Üniversitesi}, organization={TÜBİTAK}