        TY  - JOUR
T1  - The Relationship Between Oxidative Stress and Adenotonsillar Hypertrophy in Children
TT  - Çocuklarda Oksidatif Stres ile Adenotonsiller Hipertrofi Arasındaki İlişki
AU  - Alyar, Gülşah
AU  - Öztürk, Nurinnisa
AU  - Yörük, Özgür
AU  - Türkeri, Özge Nur
AU  - Bakan, Nuri
PY  - 2023
DA  - March
DO  - 10.12956/tchd.1072563
JF  - Türkiye Çocuk Hastalıkları Dergisi
JO  - Türkiye Çocuk Hast Derg
PB  - T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi
WT  - DergiPark
SN  - 1307-4490
SP  - 96
EP  - 100
VL  - 17
IS  - 2
LA  - en
AB  - Objective: In this study, it was aimed to evaluate the preoperative and postoperative oxidative stress levels of childrenwith obstructive adenotonsillar hypertrophy and to compare the obtained data with healthy children.Material and Methods: 25 patients and 25 healthy controls were included in the prospective study conducted betweenMarch and September 2015. In the study sample, children who were diagnosed with adenotonsillar hypertrophy dueto chronic tonsillitis, snoring and mouth breathing and who were planned for adenotonsillectomy were included inthe patient group. Control group included 25 healthy volunteers with the same demographic characteristics. Serumand urine samples were collected from the patient group twice, before and after surgery, and once from the controlgroup. 8-hydroxy-2-deoxyguanosine levels of all samples were determined by EIA method, protein carbonyl levels weredetermined by ELISA method and malondialdehyde levels were determined by manual spectrophotometric method.Results: In the study, it was found that the serum malondialdehyde levels of children with adenotonsillar hypertrophywere significantly higher than the control group (p=0.003) and that there was no difference in terms of other parameters(p&amp;gt;0.05). After the operation, it was determined that the levels of all three parameters evaluated significantly decreasedcompared to before (p&amp;lt;0.05). It was determined that there was a statistically significant and weak correlation betweenmalondialdehyde and 8-hydroxy-2-deoxyguanosine values before the operation (p=0.003, r=0.566).Conclusion: Hypertrophic adenotonsillar, which is common in the pediatric population, causes many clinical conditionsand adversely affects the health and quality of life of children. In line with our findings, we can say that serum and urine MDAlevels and tissue PCO levels are useful markers in the evaluation of oxidative damage in children with obstructive ATH andmay help to elucidate the etiopathogenesis of the disease. Considering the effects of ATH on health, it is recommendedto be considered as an important health problem and to examine the clinical, biochemical and histopathological studiesof the disease in a larger sample group.
KW  - Adenotonsillar hypertrophy
KW  - 8-hydroxy-2-deoxyguanosine
KW  - malondialdehyde
KW  - protein carbonyl
N2  - Amaç: Bu çalışmada obstrüktif adenotonsiller hipertrofisi olan çocukların ameliyat öncesi ve sonrası oksidatif stres düzeylerinin değerlendirilmesi ve elde edilen verilerin sağlıklı çocuklarla karşılaştırılması amaçlandı. Gereç ve Yöntemler: 2015 yılı Mart-Eylül ayları arasında yapılan prospektif çalışmaya 25 hasta ve 25 sağlıklı kontrol dahil edilmiştir.Araştırma örnekleminde hasta grubuna kronik tonsillit, horlama ve ağızdan nefes alma şikayeti ile adenotonsiller hipertrofi tanısı alan veadenotonsillektomi planlanan çocuklar dahil edilmiştir. Serum ve idrar örneği hasta grubundan ameliyat öncesi ve sonrası iki kez, kontrolgrubundan bir kez alındı. Tüm numunelerin 8-hidroksi-2-deoksiguanozin düzeyleri EIA yöntem, protein karbonil düzeyleri ELISA yöntem vemalondialdehit düzeyleri manuel spektrofotometrik yöntem kullanılarak belirlenmiştir.Bulgular: Çalışmada adenotonsiller hipertrofisi olan çocukların serum malondialdehit düzeylerinin kontrol grubuna göre anlamlı olarakyüksek olduğu (p=0.003) ve diğer parametreler açısından fark olmadığı (p&amp;gt;0.05) bulunmuştur. Ameliyattan sonra değerlendirilen her üçparametrenin de öncekine göre anlamlı düzeyde azaldığı tespit edilmiştir (p&amp;lt;0.05). Operasyon öncesi malondialdehit ile 8-hidroksi-2-deoksiguanozin değerleri arasında istatistiksel olarak anlamlı ve zayıf bir korelasyon olduğu belirlenmiştir (p=0.003, r=0.566).Sonuç: Pediatrik popülasyonda yaygın görülen hipertrofik adenotonsiller birçok klinik duruma neden olarak çocukların sağlığını ve yaşamkalitesini olumsuz etkilemektedir. Bulgularımız doğrultusunda obstrüktif ATH’li çocuklarda serum ve idrar MDA düzeyleri ile doku PCOdüzeylerinin oksidatif hasarın değerlendirilmesinde yararlı belirteçler olduğunu ve hastalığın etyopatogenezini aydınlatmaya yardımcı olabileceğinisöyleyebiliriz. ATH sağlık üzerindeki olumsuz etkileri sebebiyle hastalığın klinik, biyokimyasal ve histopatolojik çalışmalarının dahageniş bir örneklem grubunda incelenmesi önerilmektedir.Anahtar Sözcükler: Adenotonsiller hipertrofi, 8-hidroksi-2-
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UR  - https://doi.org/10.12956/tchd.1072563
L1  - https://dergipark.org.tr/tr/download/article-file/2249664
ER  -