TY - JOUR T1 - Analysis of Atenolol in Rabbit Plasma by HPLC Method AU - Yilmaz, Bilal PY - 2023 DA - March DO - 10.18185/erzifbed.1083703 JF - Erzincan University Journal of Science and Technology PB - Erzincan Binali Yıldırım Üniversitesi WT - DergiPark SN - 2149-4584 SP - 1 EP - 10 VL - 16 IS - 1 LA - en AB - The goal of this research is to develop a high-performance liquid chromatography method for analyzing atenolol levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of atenolol was achieved on an Ace C18 column. The method’s calibration curve was plotted between 5 and 250 ng/mL. The accuracy results were better than 2.97% and the precision results were less than 6.30% in rabbit plasma for atenolol. The method had recovery values >95.8% for all samples in rabbit plasma. In addition, the validated method was used to study atenolol pharmacokinetics in rabbits. 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