TY - JOUR T1 - Cardiac effects of Sugammadex and Rocuronium combination in rats: experimental study AU - Yılmaz, Nezir AU - Doğukan, Mevlüt AU - Annaç, Ebru AU - Doğan, Zümrüt AU - Üçkardeş, Fatih AU - Uludag, Öznur PY - 2022 DA - July DO - 10.38053/acmj.1088069 JF - Anatolian Current Medical Journal JO - Anatolian Curr Med J / ACMJ / acmj PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2718-0115 SP - 244 EP - 248 VL - 4 IS - 3 LA - en AB - Aim: In this experimental study, it was aimed to examine the effects of rocuronium and sugammadex complex on cardiac muscle cells in rats histopathologically and biochemically. Matherial and Method: 32 adult Sprague-Dawley male rats were divided into four groups with 8 in each group. Group 1 consisted of animals that did not undergo surgical treatment. Group 2 received a volume equivalent to 16 mg/kg sugammadex with 0.9% intravenous saline. Group 3 received 16 mg/kg of intravenous sugammadex. Group 4, 1 mg/kg intravenous rocuronium and 16 mg/kg intravenous sugammadex were administered to rats. After the procedure completed GSH and MDA level evaluated biochemically; and heart tissue evaluated histopathologically. Results: In group 4, connective tissue edema between muscle fibers was observed to be significantly increased, vessel dilatation and hemorrhagic areas were observed. Groups 3 and 4 were found to cause an increase in GSH level when compared to Groups 1 and 2, and a decrease in MDA level in these two groups compared to the others. Conclusion: Although sugammadex and sugammadex-rocuronıum complex cause biochemical and histopathological effect on the heart tissue, there were no irreversible histopathologic changes and no significant biochemical difference found in this study. KW - Sugammadex KW - rocuronium KW - cardiac muscle KW - histopathology KW - rat CR - Fisher DM. Clinical pharmacology of neuromuscular blocking agents. Am J Health Syst Pharm 1999; 56: 4–9. 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