@article{article_1093358, title={Stem Cell Therapy in Rats with Experimental Intrauterine Adhesions Induced by Trichloroacetic Acid}, journal={Environmental Toxicology and Ecology}, volume={2}, pages={40–49}, year={2022}, author={Öztürk, Şamil and Özçelik Otcu, Serap Mutlu and Özdemir, İlhan and İrkin, Latife Ceyda}, keywords={Kök hücre, İntrauterin adezyon, rat, histoloji}, abstract={The effectiveness and role of stem cells obtained from bone marrow in removing the adhesion formed in intrauterine adhesion modeling using chemicals in rats and restoring the implantation of the blastocyst to the endometrium were investigated. The experimental model was created in a single horn using trichloroacetic acid. Three different groups and two subgroups were formed as only culture medium (CM), stem cell and 48-hour medium (Niche). A total of 30 female and 3 male rats were used in the study. Treatment was started immediately after model formation in the acute phase, and 10 days later, the subjects were placed in the same cage with male rats for conception. Then, the pregnancy status and the number of puppies born were evaluated. Histological evaluation was performed with hematoxylin-eosin staining.A statistically significant difference (p <0.05) was found in the stem cell applied groups compared to the other groups in both histological and morphological evaluations according to the number of newborns. It has been determined that regional stem cell application in the acute period can remove adhesions in uterine adhesions and make the endometrium more suitable for implantation. As a result, the increase in the number of newborns as a result of the increase in endometrial thickness, number of glands and vascularization, decrease in fibrous areas and regression of adhesive areas in the treatment groups is promising in terms of carrying experimental intrauterine studies to the clinic.}, number={1}, publisher={Ekoloji ve Ekotoksikoloji Derneği}