TY - JOUR T1 - Investigation of the role of CYP1A1 and CYP1B1 expressions in obesity susceptibility AU - Oğuztüzün, Serpil AU - Polat, Fatih AU - Buluş, Hakan AU - Kaygın, Pınar AU - Dirican, Onur AU - Güler Şimşek, Gülçin AU - Sarıaltın, Sezen Yılmaz AU - Gürbüz, Fatıma Nurdan AU - Yılmaz, Can PY - 2022 DA - September DO - 10.46810/tdfd.1109600 JF - Türk Doğa ve Fen Dergisi JO - TJNS PB - Bingöl Üniversitesi WT - DergiPark SN - 2149-6366 SP - 69 EP - 78 VL - 11 IS - 3 LA - en AB - Metabolik işleyiş, etkileri ve neden olduğu hastalıklar açısından daha multidisipliner bir bakış açısıyla anlaşılması gereken obezite, son yıllarda prevalansı ve insidansı artan hastalıklardan biri olarak görülmektedir. Bu hastalığın metabolik yolunda önemli enzim gruplarından biri olan sitokrom p450 (CYP1A1 ve CYP1B1) izozimlerinin rolünün ortaya konulması amaçlanmıştır. 2017-2019 yılları arasında Ankara Keçiören Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği'nde obezite tanısı konulan ve bariatrik cerrahi, ksenobiyotik metabolizması uygulanan 152 hastaya immünohistokimya yöntemiyle CYP1A1 ve CYPB1 izoenzimlerinin ekspresyonu araştırılmıştır. CYP1A1 açısından elde edilen bulgular; 152 kişide CYP1A1 ve CYP1B1 immünohistokimya boyama düzeyleri incelenen dokuların %12.7'sinde CYP1A1 ekspresyonu gözlenmezken; %33.3, %32.5 ve %21.4'te zayıf bir CYP1A1 ifadesi gözlenmiştir. Dokuların %71.4'ünde CYP1B1 ekspresyonu görülmezken, dokuların %28.6'sında zayıf ekspresyon izlenmiştir. Hiçbir dokuda orta veya güçlü CYP1B1 ekspresyonu gözlenmemiştir. Kadın hastalardan alınan dokuların ortalama CYP1A1 ve CYP1B1 boyama seviyeleri erkek hastalardan daha yüksek bulunmuştur. 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