@article{article_1116792, title={A Potential Plant for Wound Dressing: Evaluation of the Pharmacological Activities of Polygonum Cognatum Meissn with a 3D Cell Culture Perspective}, journal={IZTU Journal of Medical and Health Sciences}, volume={1}, pages={75–80}, author={Karabay, Ufkay and Bakan, Sıla Aze and Husemoglu, R. Bugra and Yuksel Egrılmez, Mehtap}, keywords={Polygonum Cognatum Meissn., Yara İyileşmesi, İnflamasyon, 3B Doku İskelesi}, abstract={A physiologic wound healing is a complex multi-faceted process regulated by the hemostasis/inflammation, proliferation, and remodelling phases. In order to better understand the wound healing mechanism, novel reports are published in the literature with in vitro and in vivo wound models. Tissue repair may progress insufficiently in autoimmune, diabetic, pressure and burn wounds. In this regard, patients with like these wounds may need to be treated with cellular therapy. Regenerative medicine is an interdisciplinary field of study in which life sciences apply engineering principles to heal and repair diseased and injured tissues and restore and maintain normal function. Polygonum cognatum Meissn (P. cognatum) is an antioxidant and antimicrobial perennial wild edible plant belonging to the Polygonaceae family that is rich in crude protein, vitamin C and E, carotenoids, Zn, Fe and, Mn elements, folic acid. In this review, we aimed to summarize the pharmacological properties of P. cognatum and its potential use as a candidate for 3D scaffolds. The literature search from the database PubMed and Google Scholar was done for the keyword “Polygonum Cognatum” and 15 articles were identified. P. cognatum leaves as a 3D tissue scaffold by decellularization may present a unique approach as a skin wound dressing.}, number={2}, publisher={İzmir Tınaztepe Üniversitesi}