TY  - JOUR
T1  - A Simple and High Throughput Methodology for Simultaneous Determination of Levodopa and Carbidopa
AU  - Özdokur, Kemal Volkan
AU  - Kırlangıç, İrem
AU  - Ertas, Fatma Nil
PY  - 2022
DA  - December
Y2  - 2022
DO  - 10.51435/turkjac.1119121
JF  - Turkish Journal of Analytical Chemistry
JO  - TurkJAC
PB  - Miraç OCAK
WT  - DergiPark
SN  - 2687-6698
SP  - 52
EP  - 58
VL  - 4
IS  - 2
LA  - en
AB  - Parkinson's disease (PD) is a degenerative disorder of the central nervous system. The motor symptoms of PD disease result from the death of dopamine-generating cells in a region of the mid brain and the dopamine precursor levodopa (L-Dopa) is used for the treatment. Carbidopa (Car) is administered in association with L-Dopa in pharmaceutical formulation as an inhibitor on the decarboxylase activity. Thus, their simultaneous determination is of great importance because of their co-existence in pharmaceutical preparations. Present study deals with a simple method development for simultaneous voltammetric determination of L-Dopa and Car at a pencil graphite electrode (PGE) via monitoring the reduction peak of L-Dopa and the second oxidation peak of Car. The sensitivity of the method was found comparable to other methods depending on the sophisticated electrode modifications and the limits of detection were calculated as sub micromolar levels.
KW  - L-Dopa
KW  - Carbidopa
KW  - pencil graphite electrode
KW  - cyclic voltammetry
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UR  - https://doi.org/10.51435/turkjac.1119121
L1  - https://dergipark.org.tr/tr/download/article-file/2438334
ER  -