TY - JOUR T1 - Kronik Hepatit C Hastalarında Uygulanan Direkt Etkili Antiviral Tedavinin Yaşam Kalitesi Üzerine Uzun Dönem Etkisinin Değerlendirilmesi TT - Evaluation of the Long-Term Effect of Direct-Acting Antiviral Treatment on Quality of Life in Chronic Hepatitis C Patients AU - Gök Sargın, Zeynep AU - Yılmaz, Doğancan AU - Düşünceli, İbrahimhalil AU - Üstündağ, Yücel PY - 2022 DA - December Y2 - 2022 DO - 10.29058/mjwbs.1123005 JF - Medical Journal of Western Black Sea JO - Med J West Black Sea PB - Zonguldak Bülent Ecevit Üniversitesi WT - DergiPark SN - 2822-4302 SP - 329 EP - 337 VL - 6 IS - 3 LA - tr AB - Amaç:Kronik hepatit C (KHC) hastalarında, küratif etkinliği yüksek, direkt etkili antiviraller (DAA) ile tedavi sonrası uzun dönemde öz bakım, günlük aktiviteler, ağrı ve emosyonel açıdan hayat kalitesindeki değişimi değerlendirmeyi amaçladık.Gereç ve Yöntemler :KHC nedeniyle Ocak 2017 ile Haziran 2021 tarihleri arasında DAA tedavisi tamamlanmış olan hastalara günlük yaşam aktiviteleri, öz bakım yeterlilikleri, ağrı seviyeleri, anksiyete ve depresyon varlığını ölçen EQ-5D-3L Genel Yaşam Kalitesi Ölçeği soruları tedavi öncesi ve tedavi sonrası karşılaştırma yapmak amacıyla yöneltildi. DAA tedavisi ile kalıcı viral yanıt sonrası en az 12 ay geçmiş hastalar çalışmaya alındı. Bulgular:Çalışmaya alınan 90 hastanın ortalama takip süresi 40 ±17.3 aydı. DAA tedavisi sonrası en az bir yıl sonra tüm hastaların yaşam kalitesi indekslerinde tedavi öncesine göre anlamlı olarak artış izlenmiştir (p KW - Kronik hepatit C KW - Direkt etkili antiviral tedavi KW - Kalıcı viral yanıt KW - Yaşam kalitesi N2 - Aim :It was aimed to evaluate the long-term changes in self-care, daily activities, pain and emotional quality of life after treatment with direct-acting antivirals (DAA) in chronic hepatitis C (CHC) patients.Materials and Methods:EQ-5D-3L General Quality of Life Scale questions measuring activities of daily, self-care efficacy, pain levels, anxiety, and depression in patients who completed DAA treatment for CHC between January 2017 and June 2021 was used to compare before and after treatment. Patients at least 12 months after sustained viral response with DAA treatment were included in the study.Results:The mean follow-up period of 90 patients was 40 ±17.3 months. A significant increase was observed in the quality of life indices of all patients at least one year after DAA treatment (p CR - KAYNAKLAR 1. Roudot-Thoraval F. Epidemiology of hepatitis C virus infection. Clin Res Hepatol Gastroenterol. 2021; 45:3. CR - 2. Hepatitis C. [cited 2022 May]. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-c CR - 3. Kleinman L, Mannix S, et al. Review of patient-reported outcome measures in chronic hepatitis C. Health Qual Life Outcomes. 2012; 10: 92 CR - 4. Gallach M, Vergara M, et al. Impact of treatment with direct-acting antivirals on anxiety and depression in chronic hepatitis C. PLoS One. 2018; 13: 12. CR - 5. 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UR - https://doi.org/10.29058/mjwbs.1123005 L1 - https://dergipark.org.tr/tr/download/article-file/2454299 ER -