TY - JOUR T1 - Comparison of the Effects of Different Molecular Weight Hyaluronic Acid Application in Knee Osteoarthritis TT - Diz Osteoartritinde Farklı Molekül Ağırlıklı Hyaluronik Asit Uygulamalarının Etkilerinin Karşılaştırılması AU - Çoştu, Ali PY - 2022 DA - November Y2 - 2022 DO - 10.16899/jcm.1123734 JF - Journal of Contemporary Medicine JO - J Contemp Med PB - Rabia YILMAZ WT - DergiPark SN - 2667-7180 SP - 973 EP - 977 VL - 12 IS - 6 LA - en AB - Objective: The objective of this study was to evaluate the effect of different molecular weight (MW) hyaluronic acid (HA) application on pain and functional parameters in knee osteoarthritis (OA).Methods: This study was designed as retrospectively. Hospital records of the patients who received intraarticular HA injection therapy in our center were screened. The patients were divided into 3 categories according to the MW of the preparates as the follows; Group 1: 0,6-1,2 Milion Da of MW (N=26); Group 2: 1,1- 2,2 Million Da of MW (N=25); and Group 3: 1,7-2,1 Million Da of MW (N=25). All patients were assessed using Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) before the treatment and one month after the injection.Results: A total of 76 patients (61 females, 15 males) with a mean age of 62,1 years (minimum-maximum: 50-70 years) were included. VAS and WOMAC scores did improve significantly in all groups (all for p KW - knee osteoarthritis KW - hyaluronic acid KW - pain N2 - Amaç: Bu çalışmanın amacı, diz osteoartritinde (OA) farklı moleküler ağırlıklı (MA) hyaluronik asit (HA) uygulamasının ağrı ve fonksiyonel parametreler üzerindeki etkisini değerlendirmektir.Yöntemler: Bu çalışma geriye dönük olarak planlandı. Merkezimizde intraartiküler HA enjeksiyon tedavisi alan hastaların hastane kayıtları tarandı. Preparatların MA'sına göre hastalar aşağıdaki gibi 3 kategoriye ayrıldı; Grup 1: 0,6-1,2 Milyon Da MA (N=26); Grup 2: 1,1- 2,2 Milyon Da MA (N=25); ve Grup 3: 1,7-2,1 Milyon Da MA (N=25). Tüm hastalar, tedaviden önce ve enjeksiyondan bir ay sonra Görsel Analog Skala (VAS) ve Western Ontario ve McMaster Universities Arthritis Index (WOMAC) kullanılarak değerlendirildi.Bulgular: Yaş ortalaması 62,1 yıl (minimum-maksimum: 50-70 yıl) olan toplam 76 hasta (61 kadın, 15 erkek) dahil edildi. VAS ve WOMAC skorları tüm gruplarda anlamlı olarak iyileşti (tümü için p CR - 1. Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port 2015; 28:99- 106 CR - 2. Breedveld FC. Osteoarthritis the impact of a serious disease. Rheudisease Rheumatology (Oxford) 2004; 43-44 CR - 3. Kacar C, Gilgil E, Urhan S, Arikan V, Dündar U, Oksüz MC, et al. 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Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis CMAJ. 2005; 172: 1039–1043 UR - https://doi.org/10.16899/jcm.1123734 L1 - http://dergipark.org.tr/tr/download/article-file/2457356 ER -