TY - JOUR T1 - Development and Evaluation of Nanostructured Lipid Carriers for Transdermal Delivery of Ketoprofen AU - Sudheer, Preethı AU - Sathyanarayana, Thulasi AU - Jacob, Elsa AU - Sabu, Merlin Mary PY - 2023 DA - March DO - 10.55262/fabadeczacilik.1126288 JF - Fabad Eczacılık Bilimler Dergisi JO - Fabad J Pharm Sci PB - FABAD Ankara Eczacılık Bilimleri Derneği WT - DergiPark SN - 1300-4182 SP - 105 EP - 124 VL - 48 IS - 1 LA - en AB - Purpose: Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) which when administered via an oral route displays significant gastro-intestinal side effects and has low skin permeation profile. The objective of the present work is to utilise nanostructured lipid carriers (NLCs) as carrier system for transdermal delivery of ketoprofen. Methods: NLCs were prepared via hot homogenisation technique using bees wax, carnauba wax, glycerl monostearate (solid lipids), linseed oil (liquid lipid) and poloxamer188 (surfactant) and optimized using custom design via JMP. The responses evaluated were drug entrapment efficiency, particle size and drug release profile. The experimental design was evaluated for model fit with the assistance of ANOVA. The optimum formulations were characterized for particle size, zeta potential, SEM, DSC, FTIR and also drug content, entrapment efficiency, in- vitro drug release, ex-vivo drug release profile was studied.Results: The drug entrapment in the range of 34±0.03-95.06±0.01%. The drug release from the formulations over a 24 h study was found to be 80%±0.09 to 95%±0.06. The maximum desirability was found to be 0.91. The optimum formulation showed mean particle size of 425.8nm and a zeta potential of -45mV. SEM results revealed slightly agglomerated particles with uneven surfaces. The ex-vivo skin permeation of NLC optimized patch formulation exhibited a higher flux and permeability coefficient in comparison to the pure drug patch formulation and marketed gel (2.5%w/w) FTIR spectra assured the chemical and physical compatibility. Conclusion: Transdermal delivery of ketoprofen via NLCs would be a promising approach for improving the skin permeation. KW - Ketoprofen KW - permeation KW - NLC KW - Skin KW - yağlar KW - optimizasyon KW - Ex-vivo KW - Flux CR - Reference1 Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A. Nanostructured lipid carriers (NLC): A potential delivery system for bioactive food molecules. Innov Food Sci Emerging T. 2013; 19:29-43.http://dx.doi.org/10.1016%2Fj.ifset.2013.03.002 CR - Reference2 Ghasemiyeh P and Mohammadi-Samani S. 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Int J Pharm. 2014;471(1-2):103-11.https://doi.org/10.1016/j.ijpharm.20 UR - https://doi.org/10.55262/fabadeczacilik.1126288 L1 - https://dergipark.org.tr/tr/download/article-file/2467824 ER -