@article{article_1127928, title={The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children}, journal={Online Turkish Journal of Health Sciences}, volume={7}, pages={493–498}, year={2022}, DOI={10.26453/otjhs.1127928}, author={Durak, Cansu and Yavas Abalı, Zehra and Köksal, Muammer Osman and Beka, Hayati and Ağaçfidan, Ali and Oğuz, Prof. Dr. Fatma and Baş, Firdevs}, keywords={adolesan, Hashimoto hastalığı, otoimmün hastalık, parvovirus B19}, abstract={<div style="text-align:justify;">Objective: This study aims to determine the triggering role of parvovirus B19 (PV-B19) in the pathogenesis of autoimmune thyroiditis in adolescence. </div> <div style="text-align:justify;">Materials and Methods: Thirty-five patients aged 10-18 years who were diagnosed with Hashimoto’s thyroiditis in the last 6 months were included in the study. As the control group, 35 healthy volunteers without PV-B19 associated acute disease, no goiter in physical examination, no family history of thyroid disease, and normal thyroid function tests were recruited. Serum samples were tested for PV-B19 IgM and IgG antibodies and PV-B19 DNA. Statistical analysis was performed using the SPSS. </div> <div style="text-align:justify;">Results: PV-B19 IgM antibodies were positive in 4 (11.4%) patients and 5 (14.3%) controls whereas PV-B19 IgG antibodies were present in 13 (37.1%) patients and 6 (17.1%) controls. PV-B19 DNA was detectable in 11.4% of patients (n:4) and 14.3% of controls (n:5). There was no significant difference between the patient and control groups in terms of antibody and polymerase chain reaction positivity. In logistic regression analysis, free thyroxine level (p:0.021), anti-thyroid peroxidase antibody level (p:0.005), and isthmus thickness (p:0.021) were found to be effective on PV-B19 IgG positivity. </div> <div style="text-align:justify;">Conclusion: Previous PV-B19 infections may be one of the triggers in the pathogenesis of Hashimoto’s thyroiditis.  </div>}, number={3}, publisher={Oğuz KARABAY}