TY  - JOUR
T1  - Serum albumin and C-reactive protein/albumin ratio in community-acquired pneumonia
TT  - Toplum kökenli pnömönide serum albümin ve CRP/albümin oranının hastalık seyrine etkisi
AU  - Hoşgün, Derya
AU  - Sayın Gülensoy, Esen
AU  - Akpınar, Evrim
AU  - Ogan, Nalan
AU  - Ateş, Can
AU  - Aydemir, Semih
PY  - 2022
DA  - June
DO  - 10.47582/jompac.1128249
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / Jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 111
EP  - 116
VL  - 3
IS  - 2
LA  - en
AB  - Introduction: Community-acquired pneumonia (CAP) is a common type of respiratory tract infections with high morbidity and mortality. Prognostic role of CRP/Albumin ratio in CAP patients still is unknown. The aim of this study was to investigate the role the CRP/albumin ratio in predicting 30-day mortality and ICU requirement in hospitalized patients with CAP.Material and Method: The study included patients with CAP.Clinical records and plain radiographic images of the patients were retrieved from hospital database and were reviewed for each patient.Results: The 179 CAP patients who were hospitalized were included. CRP level and the CRP/albumin ratio were found to have no significant effect on mortality and ICU requirement (p=0.728, p=0.232, and p=0.110, respectively), whereas low albumin level was associated with high mortality and ICU requirement (p
KW  - Community-acquired pneumonia
KW  - biomarkers
KW  - mortality
KW  - prognosis
N2  - Amaç:Toplum kökenli pnömöni (TKP) solunum yolu enfeksiyonları içinde yüksek mortalite ve morbiditeye sahiptir.Tanı, tedavi, prognoz takibinde çeşitli biokimyasal markerlar kullanılmaktadır.CRP, albümin rutin uygulamada sıklıkla kullanılan biokimyasal markerlardır.İnflamasyon temellli CRP/albümin oranı çeşitli hastalıklarda prognoz tahmininde kullanılmaktadır.Postoperatif yoğun bakıma kabul edilen hastalarda yapılan çalışmalarda 30 günlük ve 1 yıllık mortalite tahmininde bağımsız risk faktörü olarak bulunmuştur.Çeşitli klinik durumlarda CRP/albümin oranı  tek başına albümin ve CRP’den  daha iyi inflamatuvar durumu yansıttığı düşünülmektedir.Bu çalışmanın amacı TKP nedeniyle hastaneye yatırılan CRP/albümin oranının 30 günlük mortalite tahminindeki rolünü belirlemekti.Çalışmanın ikincil sonlanım noktası ise yoğun bakım ihtiyacı idi. Gereç Ve Yöntem:Göğüs hastalıkları ve yoğun bakım servisine yatırılan TKP’li hastalar çalışmaya dahil edildi. Retrospektif olarak hasta dosyaları, radyolojik incelemeleri ve laboratuvar bulguları tarandı.Bulgular:Yüz(%55.9)’ü göğüs hastalıkları servisinde 79’u yoğun bakımda yatmakta olan 179 TKP’li hasta çalışmaya dahil edildi. Hastaların yaş ortalaması 72.027±12.88 yıldı, %61.5’i erkek, %38.5’i kadındı.CRP değeri ve CRP/albümin oranı 30 günlük mortalite ve yoğun bakım ihtiyacını tahmin etmede anlamlı bulunmazken (sırasıyla p:0.728, p:0.232, p:0.110), düşük albümin değerlerinin mortalite ve yoğun bakım ihtiyacı riskini anlamlı derecede artırdığı bulundu(p
CR  - Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med 2019; 200: e45-67.
CR  - Farah R, Mograbi J, Makhoul N.Impact of serum C-reactive protein measurements in the first 2 days on the 30-day mortality in hospitalized patients with severe community-acquired pneumonia: A cohort study. J Crit Care 2013; 28: 291-5.
CR  - Arnau-Barrés I, Güerri-Fernández R, Luque S, Sorli L, Vázquez O, Miralles R. Serum albumin is a strong predictor of sepsis outcome in elderly patients. Eur J Clin Microbiol Infect Dis 2019; 38: 743-6.
CR  - Eshwara VK, Mukhopadhyay C, Rello J. Community-acquired bacterial pneumonia in adults. An update. Indian J Med Res 2020; 151: 287-302.
CR  - Ranzani OT, Zampieri FG, Forte DN, Azevedo LC, Park M. C-reactive protein/albumin ratio predicts 90-day mortality of septic patients. Plos One 2013; 8: e59321.
CR  - Kocatürk M, Kocatürk O. Assessment of relationship between C-reactive protein to albumin ratio and 90-day mortality in patients with acute ischaemic stroke. Neurol Neurochir Pol 2019; 53: 205-11.
CR  - Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 2001; 163: 1730-54.
CR  - British Thoracic Society Standarts of Care Committee BTS Guidelines for the management of community acquired pneumonia in adults. Thorax 2001; 56: iV1-64.
CR  - Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD. Infectious Diseases Society of America/America Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44: S27-72.
CR  - Bouch DC, Thompson JP. Severity scoring systems in the critical ill. Continuing Education in Anesthesia and Critical Care 2018; 8: 181-5.
CR  - Metersky ML, Waterer G, Nsa W, Bratzler DW. Predictors of in-hospital vs discharge mortality in pneumonia. Chest 2012; 142: 476-81
CR  - Lee JH, Kim J, Kim K. Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia. J Crit Care 2011; 26: 287-94.
CR  - Oh TK, Eunjeong J, Hyo-seok N, et al. C-reactive protein to albumin ratio predicts 30-day and 1-year mortality in postoperative patients after admission to the intensive care unit. J Clin Med 2018; 7: 39.
CR  - Kim MH, Ahn JY, Song JE, et al. The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe or septic shock treated with early goal-directed therapy. Plos One 2015; 10: e0132109.
CR  - Oh J, Kim SH, Park KN. High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department. Clin Exp Emerg Med 2017; 4: 19-24.
CR  - Charles PG, Wolfe R, Whitby M, et al. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis 2008; 47: 375-84.
CR  - Ventura JC, Hauschild DB, Moreire MDE.C-reactive protein/albumin ratio is associated with lung function among children/adolescents with cystic fıbrosis: a three years longitudinal study. Sao Paulo Med J 2018; 136: 29-36.
CR  - Mendez R, Aldas I, Menendez R. Biomarkers in community-acquired pneumonia (cardiac and non-cardiac). J Clin Med 2020; 9: 549.
CR  - Nair GB, Niederman MS. Updates on community acquired pneumonia management in the ICU. Pharmacol Ther 2021; 217: 107663.
CR  - Sungurlu S, Balk RA. The role of biomarkers in the diagnosis and management of pneumonia. Clin Chest Med 2018; 39: 691-701.
CR  - Ugajin M, Yamaki K, Iwamura N, Yagi T, Asano T. Blood urea nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquired pneumonia. Int J Gen Med 2012; 5: 583-9.
CR  - Moncada DC, Rueda ZV, Macías A, Suárez T, Ortega H, Vélez LA. Reading and interpretation of chest X-ray in adults with community-acquired pneumonia. Braz J Infect Dis 2011; 15: 540-6.
CR  - Lanks CW, Musani A,Hsia DW. Community-acquired pneumonia and hospital acquied pneumonia. Med Clin N Am 2019; 103: 487-501.
CR  - Poetter-Lang S, Herold CJ.Community-acquired pneumonia. Radiologe 2017; 57: 6-12.
CR  - Sharma S, Maycher B, Eschun G. Radiological imaging in pneumonia: recent innovations. Curr Opion Pulm Med 2007; 13: 159-69.
UR  - https://doi.org/10.47582/jompac.1128249
L1  - https://dergipark.org.tr/tr/download/article-file/2476107
ER  -