TY  - JOUR
T1  - Papiller Tiroid Kanserli Hastalarda Preoperatif Santral Lenf Nodu Metastazının Öngörücüsü Olarak Glikoz-Lenfosit Oranı
AU  - Alkurt, Ertugrul Gazi
AU  - Turhan, Semin
AU  - Şahin, Fatih
AU  - Tutan, Mehmet Berksun
PY  - 2022
DA  - December
DO  - 10.18663/tjcl.1148122
JF  - Turkish Journal of Clinics and Laboratory
JO  - TJCL
PB  - DNT Ortadoğu Yayıncılık A.Ş.
WT  - DergiPark
SN  - 2149-8296
SP  - 534
EP  - 539
VL  - 13
IS  - 4
LA  - tr
AB  - AmaçPapillertiroid kanserinde santral lenf nodlarının metastazının cerrahi öncesi saptanması zordur. Papiller tiroid kanserinin tedavisinde santral lenf nodu diseksiyonunun rolü belirsizliğini koruyor. Bu çalışma, papiller tiroid kanserli hastalarda preoperatif santral lenf nodu metastazı oluşumunu öngörmek için hazır preoperatif klinik özelliklere dayalı bir nomogram oluşturmayı amaçladıGereç ve Yöntemler2013-2022 tarihleri arasında  bilateral total tiroidektomi yapılmış papillertiroid karsinomu tanılı hastalar tarandı ve 314 hasta çalışmaya dahil edildi. Hastaların demografik verileri, operasyon süresi, TSH, T3, T4 düzeyleri, glukoz/lenfosit oranları (GLR), patoloji raporlarındaki lenfovasküler invazyon, kapsül invazyonu ve boyun metastazı durumu retrospektif olarak taranarak not edildi. Tüm istatistiksel analizler için IBM SPSS 26.0 kullanılarak değerlendirildi. p
KW  - Papiller tiroid kanseri
KW  - Glikoz
KW  - Lenfosit
KW  - Oran
CR  - 1-	Siegel RL, Miller KD,Jemal A. Cancer statistics, 2019. CA: a cancer journal for clinicians, 2019; 69(1): 7-34.
CR  - 2-	Lim H, Devesa SS, Sosa JA, Check D, Kitahara CM. Trends in the cancer incidence and mortality in the United States, 1974-2013. Jama, 2017;17(13): 1338-48.
CR  - 3-	Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. Jama; 2006; 295(18): 2164-67.
CR  - 4-	Hay ID. Papillary thyroid carcinoma. Endocrinology and metabolism clinics of North America 1990; 19(3): 545-76.
CR  - 5-	Leboulleux S, Rubino C, Baudin E et al. Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis. The Journal of Clinical Endocrinology & Metabolism, 2005; 90(10); 5723-29.
CR  - 6-	Wang TS, Sosa JA. Thyroid surgery for differentiated thyroid cancer—recent advances and future directions. Nature Reviews Endocrinology 2018;14(11): 670-83.
CR  - 7-	Bilimoria KY,Bentrem DJ, KoCY et al. Extent of surgery affects survival for papillary thyroid cancer. Annals of surgery 2007;246(3): 375.
CR  - 8-	Calò PG, Medas F, Conzo G et al. Intraoperative neuromonitoring in thyroid surgery: Is the two-staged thyroidectomy justified? International Journal of Surgery 2017; 41: 13-20.
CR  - 9-	Zhong A, Cheng CS, Kai J, Lu R, Guo, L.Clinical significance of glucose to lymphocyte ratio (GLR) as a prognostic marker for patients with pancreatic cancer. Frontiers in Oncology 2020; 10: 520330.
CR  - 10-	Navarro J, Kang I, Hwang HK, Yoon DS, Lee WJ, Kang CM. Glucose to lymphocyte ratio as a prognostic marker in patients with resected pT2 gallbladder cancer. Journal of Surgical Research, 2019; 240: 17-29.
CR  - 11-	Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow?Lancet 2001;357:539–45.
CR  - 12-	Jayatilleke KM, Hulett MD. Heparanase and the hallmarks of cancer. J Transl Med. 2020;18(1): 453.
CR  - 13-	Kwon J, Bakhoum SF. The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer. Cancer Discov. 2020;10(1):26-39.
CR  - 14-	Mantovani A. Cancer: inflammation by remote control. Nature. 2005;435:752–753
CR  - 15-	Goeppert B, Frauenschuh L, Zucknick M et al. Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer. British journal of cancer 2013;109(10): 2665-74.
CR  - 16-	Pacifico F, Leonardi A. Role of NF-κB in thyroid cancer. Molecular and cellular endocrinology 2010; 321(1): 29-35.
CR  - 17-	Han JM, Kim TY, Jeon MJ et al. Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population. Eur J Endocrinol 2013; 168(6): 879-86.
CR  - 18-	Ulmer H,Borena W, Rapp K et al. Serum triglyceride concentrations and cancer risk in a large cohort study in Austria. British Journal of Cancer 2009; 101(7): 1202-06.
UR  - https://doi.org/10.18663/tjcl.1148122
L1  - https://dergipark.org.tr/tr/download/article-file/2554848
ER  -