@article{article_1223872, title={The Effect of Exercise on Serum Resistin and Leptin Values in Rats Fed with a High Fat Diet}, journal={Journal of Contemporary Medicine}, volume={13}, pages={82–85}, year={2023}, DOI={10.16899/jcm.1223872}, author={Bulduk, Bahattin and Günbatar, Nizamettin}, keywords={Resistin, Leptin, Exercise, High-fat diet}, abstract={Aim: This study was performed to investigate the effect of exercise on serum resistin and leptin values in rats fed with a high-fat diet. Material and Method: 24 Wistar albino male rats were used in the study. They were randomly divided into 4 groups, with 6 rats in each group. The groups were determined as the control group (C), exercise group (E), high-fat diet (HFD) group, and high-fat diet + exercise (HFDE) Group. Results: When the findings obtained in this study were evaluated statistically, it was determined that the resistin values were similar in the C, E and HFDE groups, and higher in the HFD group compared to the other groups. It was observed that resistin value increased with high-fat diet and decreased with exercise. When evaluated in terms of leptin levels, the C and E groups showed similarity, while the HFD and HFDE groups showed similarity with each other. Although exercise decreased the leptin level, which was highly increased with a high-fat diet, it was not statistically significant. Conclusion: It has been determined that feeding with a high-fat diet causes an increase in serum resistin and leptin levels, and exercise provides a significant decrease in resistin values, but is not effective in leptin levels.}, number={1}, publisher={Rabia YILMAZ}, organization={Van Yüzüncü Yıl Üniversitesi}