@article{article_1224944, title={Investigation of Polyvinyl Alcohol (PVA)-Sakacin P Interaction by Molecular Docking Method}, journal={İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi}, pages={73–80}, year={2024}, DOI={10.38079/igusabder.1224944}, author={Ünlü, Nihan and Özgen, Arzu}, keywords={Sakacin P, moleküler yerleştirme, polivinil alkol}, abstract={Aim: Group IIA bacteriocins, which contain unmodified amino acids and have antimicrobial activity, are a very broad group. Sakacins in this group are bacteriocins produced by Lactobacillus sakei. The most well-known sakacins are Sakacin A, G, K, P, and Q. In particular, Sakacin A and P are well characterized. This study aims to examine the interaction between a single monomer of PVA polymer and Sakacin P bacteriocin.
Method: In t this study, the interaction of a single monomer of PVA polymer, which is among the water-soluble, biocompatible synthetic polymers, and Sakacin P bacteriocin, which has a protein structure, was investigated by molecular docking method.
Results: As a result of our molecular docking study, the presence of binding affinity between the C2H4O monomer of PVA selected as the ligand and the Sakacin P protein selected as the receptor was determined.
Conclusion: According to the results of the analysis, the presence of a strong inhibitor was detected between the ligand and the target. Therefore, this study can serve as a template for polymer-bacteriocin materials to be produced in the laboratory.}, number={22}, publisher={İstanbul Gelişim Üniversitesi}