TY  - JOUR
T1  - Investigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM
AU  - Deveci, Engin
AU  - Öcal, Ece
AU  - Alkan Akalın, Senem
PY  - 2023
DA  - September
Y2  - 2023
DO  - 10.37990/medr.1252256
JF  - Medical Records
JO  - Med Records
PB  - Tıbbi Kayıtlar Derneği
WT  - DergiPark
SN  - 2687-4555
SP  - 445
EP  - 8
VL  - 5
IS  - 3
LA  - en
AB  - Aim: In this study, we investigated the immunohistochemical staining of Sox-9 and Caspase-6 expression in placentas of pregnant woman with gestational diabetes mellitus (GDM). Material and Methods: Placentas of 20 healthy and 20 women with GDM were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and Sox-9 and Caspase-6 immunostaining.Results: In control group, Sox-9 expression was negative in decidual and connective cells and endothelial cells. In GDM group, Sox-9 expression was increased especially in the decidual cells. For the Caspase-6 expression, Caspase-6 reaction was mainly in maternal region in control group. In GDM group, Caspase-6 reaction was increased in decidual cells, in endothelial cells and in the syncytial nodes.Conclusion: Expression of Sox-9 transformed the decidua cells and lead to apoptotic pathway via Caspase-6 expression.
KW  - Sox-9
KW  - caspase-6
KW  - GDM
KW  - placenta
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UR  - https://doi.org/10.37990/medr.1252256
L1  - https://dergipark.org.tr/tr/download/article-file/2957159
ER  -