@article{article_1252598, title={The Effect of First Dose Intravenous Antibiotherapy Administered in the Emergency Department on Prognosis in Acute Tonsillopharyngitis Cases}, journal={Yeni Yüzyıl Journal of Medical Sciences}, volume={4}, pages={77–84}, year={2023}, author={Yaşar, Serdar and Yiğit, Ece}, keywords={Farenjit, Antibakteriyel Ajanlar, Acil Tedavi}, abstract={Aim: Streptococcus pyogenes (S.pyogenes) is the most common bacterial cause of acute tonsillopharyngitis in adults. With appropriate and rapid antibiotic treatment, the duration of the disease is shortened, complications are prevented and transmission is reduced. We aimed to determine how the first dose of intravenous amoxicillin+clavulanic acid treatment administered in our emergency department affects the course of the disease in patients diagnosed with acute tonsillopharyngitis due to S. pyogenes. Material Method: Patients who applied to our emergency department and internal medicine outpatient clinic with symptoms of upper respiratory tract infection, were positive for streptococcal antigen in the rapid antigen test and scored 2 points or more according to the Centor Criteria were included in our study. Complete blood count (CBC) and C-reactive protein (CRP) levels were measured at the time of admission and at the end of 72 hours. The patients were divided into two groups: the group who received the first dose of antibiotics as 1000 mg amoxicillin and 200 mg clavulonic acid intravenously at the time of admission and then used the oral form of the same antibiotic in a 2x1 posology and the group which intravenous antibiotics were not administered at the time of admission and the same antibiotic was started directly in oral form in the same posology. It was investigated whether there was a significant difference between the leukocyte, neutrophil and CRP levels measured at the end of 72 hours between the two groups. Results: Age, gender and Centor scores did not show statistically significant differences between the groups. The change in leukocyte, neutrophil and CRP values was statistically significant in both groups when the onset and 72 hours were compared (p <0.001). The change between the groups at the beginning and at the end of 72 hours was statistically significantly different for all three parameters (p <0.001). Conclusion: It was determined that patients who received the first dose of antibiotic treatment in our emergency department had a significantly higher decrease in laboratory parameters that had increased due to infection at the end of 72 hours compared to patients who used only oral antibiotics.}, number={4}, publisher={İstanbul Yeni Yüzyıl Üniversitesi}