TY  - JOUR
T1  - Are the correlation results of HPV positive cases with cervical smear always consistent?
TT  - HPV DNA pozitif olguların servikal smear ile korelasyon sonuçları her zaman uyumlu mudur?
AU  - Aydın, Arzu Hazal
AU  - Zergeroğlu, Sema
AU  - Özkan, Zehra Sema
PY  - 2023
DA  - March
DO  - 10.47582/jompac.1258024
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / Jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 158
EP  - 162
VL  - 4
IS  - 2
LA  - en
AB  - Aim: Cervical cancer is a type of genital cancer which come second after breast cancer in women and may cause death. However, it can be prevented with screening tests by ensuring early diagnosis. Most of cervical cancers (99.7%) are associated with Human Papilloma Virus (HPV) and it is known that HPV must be present for the generation of cervical cancer. Thus, 70% of the patients have been found to be positive for HPV-16 and HPV-18. Both the association with cervical cancer and HPV and data related to development of cancer and dysplasia was researched retrospectively in this study. It was aimed to analyze and use the results by examine if the smear results of the patients and the HPV results are compatible in all HPV positive cases.Material and Method: 1050 patients who were examined by gynecologist and taken Pap smear test at the end of the examination during July 2020 and March 2022, were included in our study. In all cases the Pap test was re-evaluated by the same pathologist using the 2014 Bethesda System. High-risk HPV (HR HPV) DNA (HPV types 16,18,31,33,35,39,45,51,52,56,58,59,66,68) tests results, applied to the patients at an external center, were reviewed.  Results of patients diagnosed as LSIL, HSIL and cervical cancer by Pap smear test were evaluated again beside HPV DNA analyses and their clinical information. Chi-square test was used for statistical analysis. p
KW  - Cervix
KW  - cancer
KW  - HPV
KW  - screening
N2  - Amaç: Serviks kanseri, ölüme neden olan ve meme kanserinden sonra kadınlarda en sık görülen ikinci kanserdir. Ancak tarama testleri ile erken teşhis edilerek önlenebilen bir genital kanser türüdür. Serviks kanserlerinin çoğu (%99,7) Human Papilloma Virus (HPV) ile ilişkili olup günümüzde de servikal kanser gelişimi için HPV’nin mutlaka olması gerektiği bilinmektedir. Nitekim hastaların %70’inde HPV-16 ve HPV-18’in pozitif olduğu tespit edilmiştir. Bu çalışmada servikal kanser-HPV ilişkisi, displazi ve kanser gelişme oranları ile ilgili veriler retrospektif olarak araştırılmıştır. HPV pozitif tüm olgularda hastaların smear sonuçları ile HPV sonuçlarının uyumlu olup olmadığı kontrol edilerek sonuçların analiz edilmesi ve kullanılması planlanmıştır.Materyal ve Metod: Çalışmaya Temmuz 2020 ve Mart 2022 tarihleri arasında jinekolog tarafından muayeneleri yapılmış ve muayene sonunda Pap smear örneği alınmış 1050 olgu dahil edilmiştir. Tüm olguların Pap smear testleri patolog tarafından 2014 Bethesda sistemi kullanılarak yeniden değerlendirilmiştir. Çalışmada yer alan hastalara dış merkezde uygulanan yüksek risk HPV (HR HPV) DNA (HPV tipleri 16,18,31,33,35,39,45,51,52,56,58,59,66,68) test sonuçları tekrar gözden geçirilmiştir.Pap testte düşük dereceli skuamöz intraepitelyal lezyon (LSIL), yüksek dereceli skuamöz intraepitelyal lezyon (HSIL) ve servikal kanser bulguları saptanan ve HPV DNA analizi yapılan hastaların sonuçları ve dosya bilgilerinde yer alan diğer veriler yeniden değerlendirilmiştir. İstatistiksel analiz için Ki-kare testi kullanılmıştır ve p
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UR  - https://doi.org/10.47582/jompac.1258024
L1  - https://dergipark.org.tr/tr/download/article-file/2980719
ER  -