TY  - JOUR
T1  - Pediyatrik Kalp Cerrahisinde D Vitamini Eksikliği
AU  - Karacaer, Feride
PY  - 2023
DA  - June
Y2  - 2023
DO  - 10.17827/aktd.1266273
JF  - Arşiv Kaynak Tarama Dergisi
JO  - aktd
PB  - Çukurova Üniversitesi
WT  - DergiPark
SN  - 1300-3755
SP  - 102
EP  - 108
VL  - 32
IS  - 2
LA  - tr
AB  - D vitamini, çoklu organ sistemlerinin düzgün çalışması için önemli bir hormondur. Konjenital kalp hastalığı olan çocuklarda D vitamini eksikliği sık görülmekte ve kardiyopulmoner baypas uygulaması serum D vitamini düzeylerinde akut düşüşle sonuçlanmaktadır. Düşük D vitamini seviyeleri, kritik hastalarda uzamış mekanik ventilasyon ve hastanede ve yoğun bakım ünitesinde yatış süresinde uzama ile ilişkili potansiyel bir risk faktörü oluşturur. Ayrıca postoperatif düşük D vitamini seviyeleri inotropik destek gereksinimini arttırmaktadır. Postoperatif D vitamini eksikliği, kardiyovasküler disfonksiyon ve klinik seyir arasında gözlenen ilişkiler, D vitamini düzeylerinin perioperatif optimizasyonunun hasta sonuçlarını iyileştirebileceğini düşündürmektedir.
KW  - D vitamini
KW  - konjenital kalp hastalığı
KW  - kardiyopulmoner baypas
CR  - 1.	Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890-900.
CR  - 2.	Brix-Christensen V. The systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children. Acta Anaesthesiol Scand 2001;45:671-9.
CR  - 3.	Gazit AZ, Huddleston CB, Checchia PA, Fehr J, Pezzella AT. Care of the pediatric cardiac surgery patient--part 1. Curr Probl Surg 2010;47:185-250.
CR  - 4.	Cholette JM, Faraoni D, Goobie SM, Ferraris V, Hassan N. Patient Blood Management in Pediatric Cardiac Surgery: A Review. Anesth Analg. 2018;127:1002-16.
CR  - 5.	Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008; 88:491–9.
CR  - 6.	Cantorna MT, Zhu Y, Froicu M, Wittke A.  Vitamin D status, 1,25- dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80:1717–20.
CR  - 7.	Van den Berghe G. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab 2003; 88:4623–32.
CR  - 8.	Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology.2011;134:123-39.
CR  - 9.	Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS One 2013;8:e58725.
CR  - 10.	Pilz S, Ma¨rz W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, et al. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab. 2008;93:3927–35.
CR  - 11.	Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, Hart PH. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit. Care Med. 2011;183:1336–43
CR  - 12.	McNally JD, Menon K. Vitamin D deficiency in surgical congenital heart disease: prevalence and relevance. Transl Pediatr. 2013;2:99-111.
CR  - 13.	McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al Dirbashi OY, et al. Impact of anesthesia and surgery for congenital heart disease on the vitamin D status of infants and children: a prospective longitudinal study. Anesthesiology.2013;119:71–80.
CR  - 14.	Graham EM, Taylor SN, Zyblewski SC, Wolf B, Bradley SM, Hollis BW, et al. Vitamin D status in neonates undergoing cardiac operations: relationship to cardiopulmonary bypass and association with outcomes. J Pediatr. 2013;162:823–6.
CR  - 15.	Fraser DR. Vitamin D. Lancet 1995;345:104–7
CR  - 16.	Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Global consensus recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab. 2016;101:394–415.
CR  - 17.	Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.
CR  - 18.	Society for Adolescent Health and Medicine. Recommended vitamin D intake and management of low vitamin D status in adolescents: a position statement of the society for adolescent health and medicine. J Adolesc Health. 2013;52:801–3.
CR  - 19.	Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009;19:73-8.
CR  - 20.	Hart GR, Furniss JL, Laurie D, Durham SK. Measurement of vitamin D status: background, clinical use, and methodologies. Clin Lab 2006;52:335-43.
CR  - 21.	Van den Ouweland JM, Vogeser M, Bächer S. Vitamin D and metabolites measurement by tandem mass spectrometry. Rev Endocr Metab Disord 2013;14:159-84.
CR  - 22.	Singh RJ, Taylor RL, Reddy GS, Grebe SKG. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab 2006;91:3055-61.
CR  - 23.	Santillán GE, Vazquez G, Boland RL. Activation of a betaadrenergic-sensitive signal transduction pathway by the secosteroid hormone 1,25-(OH)2-vitamin D3 in chick heart. J Mol Cell Cardiol 1999; 31:1095–104
CR  - 24.	Green JJ, Robinson DA, Wilson GE, Simpson RU, Westfall MV. Calcitriol modulation of cardiac contractile performance via protein kinase C. J Mol Cell Cardiol 2006; 41:350–9
CR  - 25.	Weishaar RE, Simpson RU. Vitamin D3 and cardiovascular function in rats. J Clin Invest. 1987;79:1706–12.
CR  - 26.	Uysal S, Kalayci AG, Baysal K. Cardiac functions in children with vitamin D deficiency rickets. Pediatr Cardiol. 1999; 20:283–6.
CR  - 27.	Maiya S, Sullivan I, Allgrove J, Yates R, Malone M, Brain C, et al. Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening33 infant heart failure. Heart. 2008;94:581–4.
CR  - 28.	Kumar M, Saikia D, Kumar V, Tomar R. Vitamin D deficiency presenting with cardiogenic shock in an infant. Ann Pediatr Cardiol. 2011; 4:207–9.
CR  - 29.	Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R, Stehle P. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol. 2003;41:105–12
CR  - 30.	Rippel C, South M, Butt WW, Shekerdemian LS. Vitamin D status in critically ill children. Intensive Care Med. 2012;38:2055-62.
CR  - 31.	Dohain AM, Almogati J, Al-Radi OO, Elassal AA, Zaher ZF, Fatani TH, Abdulgawad A, Abdelmohsen G.Serum vitamin D status following pediatric cardiac surgery and association with clinical outcome. Eur J Pediatr. 2020;179:635-43.
CR  - 32.	Markestad T, Aksnes L, Finne PH, Aarskog D. Effect of exchange transfusions with citrated blood on plasma concentrations of vitamin D metabolites in neonates. Pediatr Res. 1984; 18:429–31.
CR  - 33.	Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005; 19:1067–77
CR  - 34.	Abu-Amer Y, Bar-Shavit Z. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cell Immunol. 1993; 151:356–68
CR  - 35.	Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr. 2004;58:563–7.
CR  - 36.	Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey. Arch Intern Med. 2009;169:384–90
CR  - 37.	Schott GD, Wills MR. Muscle weakness in osteomalacia. Lancet 1976; 1:626–9
CR  - 38.	Schmid E, Krajewski S, Bachmann D, Kurz J, Wendel HP, Rosenberger P, et al. The volatile anesthetic sevoflurane inhibits activation of neutrophil granulocytes during simulated extracorporeal circulation. Int J Immunopharmacol. 2012;14:202–8.
CR  - 39.	Shedeed SA. Vitamin D supplementation in infants with chronic congestive heart failure. Pediatr Cardiol. 2012;33:713-9.
CR  - 40.	Smith EM, Tangpricha V. Vitamin D and anemia: insights into an emerging association. Curr Opin Endocrinol Diabetes Obes. 2015;22:432–8.
CR  - 41.	Kumar VA, Kujubu DA, Sim JJ, Rasgon SA, Yang PS. Vitamin D supplementation and recombinant human erythropoietin utilization in vitamin D-deficient hemodialysis patients. J Nephrol. 2011;24:98–105.
CR  - 42.	Uwaezuoke SN. Vitamin D deficiency and anemia risk in children: a review of emerging evidence. Pediatric Health Med Ther. 2017 May 10;8:47-55.
CR  - 43.	Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–23.
CR  - 44.	Polhamus B, Dalenius K, Thompson D, Scanlon K, Borland E, Smith B, et al. Pediatric nutrition surveillance. Nutr Clin Care. 2003; 6:132–4.
CR  - 45.	Atkinson MA, Melamed ML, Kumar J, Roy CN, Miller ER 3rd, Furth SL, et al. Vitamin D, race, and risk for anemia in children. J Pediatr. 2014;164:153-8.
CR  - 46.	Redlin M, Kukucka M, Boettcher W, Schoenfeld H, Huebler M, Kuppe H, et al. Blood transfusion determines postoperative morbidity in pediatric cardiac surgery applying a comprehensive blood-sparing approach. J Thorac Cardiovasc Surg. 2013;146:537–42.
CR  - 47.	Antonucci R, Locci C, Clemente MG, Chicconi E, Antonucci L. Vitamin D deficiency in childhood: old lessons and current challenges. J Pediatr Endocrinol Metab. 2018;31:247-60.
CR  - 48.	Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
CR  - 49.	Brown LL, Cohen B, Tabor D, Zappala G, Maruvada P, Coates PM. The vitamin D paradox in Black Americans: A systems-based approach to investigating clinical practice, research, and public health—expert panel meeting report. BMC Proceedings. 2018;12(Suppl 6):6.
CR  - 50.	Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, et al. Vitamin D and calcium: a systematic review of health outcomes. Evid Rep Technol Assess (Full Rep). 2009;183:1-420.
CR  - 51.	Emel T, Doğan DA, Erdem G, Öktem F. Therapy strategies in vitamin D deficiency with or without rickets: efficiency of low-dose stoss therapy. J Pediatr Endocrinol Metab. 2012;25:107-10.
CR  - 52.	Soliman AT, El-Dabbagh M, Adel A, Al Ali M, Bedair EMA, Elalaily RK. Clinical responses to a mega-dose of vitamin D3 in infants and toddlers with vitamin D deficiency rickets. J Trop Pediatr. 2010;56:19-26.
CR  - 53.	Holmlund-Suila E, Viljakainen H, Hytinantti T, Lamberg-Allardt C, Andersson S, Mäkitie O. High-dose vitamin d intervention in infants--effects on vitamin d status, calcium homeostasis, and bone strength. J Clin Endocrinol Metab. 2012;97:4139-47.
CR  - 54.	Munns C, Zacharin MR, Rodda CP, Batch JA, Morley R, Cranswick NE, et al. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. Med J Aust. 2006;185:268-72.
UR  - https://doi.org/10.17827/aktd.1266273
L1  - https://dergipark.org.tr/tr/download/article-file/3015518
ER  -