TY - JOUR T1 - Retrospective evaluation of COVID-19 incidence during smoking cessation treatment with varenicline TT - Sigara Bırakma Tedavisi Olarak Vareniklin Kullanan Hastalarda COVID-19 Insidansının Retrospektif Değerlendirilmesi AU - Barış, Elif AU - Ömeroğlu Şimşek, Gökçen AU - Arici, Aylin AU - Gümüştekin, Mukaddes AU - Kılınç, Oğuz AU - Tosun, Metiner PY - 2024 DA - March DO - 10.34087/cbusbed.1276244 JF - Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi JO - CBU-SBED PB - Manisa Celal Bayar Üniversitesi WT - DergiPark SN - 2147-9607 SP - 30 EP - 35 VL - 11 IS - 1 LA - en AB - Background: Cholinergic anti-inflammatory pathway endogenously controls inflammatory processes through activation of the α7-nicotinic acetylcholine receptor (α7nAChR). Varenicline, used in smoking cessation therapy, is a full α7nAChR agonist with anti-inflammatory effects. In this study, the frequency of coronavirus disease (COVID-19) was evaluated in patients using varenicline as a smoking cessation treatment.Methods: In this retrospective cross-sectional study, records of the 111 patients admitted to Smoking Cessation Outpatient Clinic of Dokuz Eylul University Faculty of Medicine during the COVID-19 pandemic were evaluated. The development of COVID-19 disease according to the status of the patients being positive for SARS-COV-2 was evaluated comparatively in patients who received varenicline or not. Additionally, the disease symptoms were questioned. Results: SARS-CoV-2 PCR positivity was not detected in any of 38 patients who regularly used varenicline out of 68 patients evaluated. SARS-CoV-2 PCR positivity was detected in 13 (43.3%) of 30 patients who received other treatments or irregularly used varenicline (p KW - COVID-19 KW - SARS-CoV-2 KW - Retrospective Study KW - Smoking Cessation Therapy KW - Varenicline N2 - Giriş ve Amaç: Kolinerjik anti-inflamatuar yol, α7-nikotinik asetilkolin reseptörünün (α7nAChR) aktivasyonu ile inflamatuar süreçlerin endojen kontrolünü sağlamaktadır. Sigarayı bırakma tedavisinde kullanılan vareniklin, bir α7nAChR’lerine agonist etkisi ile anti-inflamatuvar etkiler ortaya çıkarmaktadır. Bu çalışmada sigara bırakma tedavisi olarak vareniklin kullanan hastalarda koronavirüs hastalığı (COVID-19) görülme sıklığı değerlendirilmiştir.Yöntemler: Bu retrospektif kesitsel çalışmada, COVID-19 pandemisi sırasında Dokuz Eylül Üniversitesi Tıp Fakültesi Sigara Bırakma Polikliniği'ne başvuran 111 hastanın kayıtları değerlendirilmiştir. SARS-COV-2 PCR pozitif olan hastalarda COVID-19 gelişimi ve hastalık belirtileri, vareniklin kullanan ve kullanmayan hastalarda karşılaştırmalı olarak değerlendirilmiştir. Bulgular: Değerlendirilen 68 hastadan düzenli olarak vareniklin kullanan 38 hastada SARS-CoV-2 PCR pozitifliği saptanmamıştır. Sigara bırakma amacıyla farklı tedavileri alan veya düzensiz vareniklin kullanan 30 hastanın 13'ünde (%43,3) SARS-CoV-2 PCR pozitifliği saptanmıştır (p CR - 1. Organization WH. Therapeutics and COVID-19: living guideline n.d.:1–98. CR - 2. Conti P, Ronconi G, Caraffa A, Gallenga C, Ross R, Frydas I, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by COVID-19: anti-inflammatory strategies. J Biol Regul Homeost Agents 2020;34. CR - 3. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical fatures of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506. CR - 4. 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