TY  - JOUR
T1  - Mucoadhesive Drug Delivery Systems for Pediatric and Geriatric Patients
AU  - Singh, Inderbir
AU  - Rai, Arya
AU  - Rawat, Shristhi Sohan
AU  - Rathi, Ritu
AU  - Raina, Deepika
AU  - Odeku, Oluwatoyin A.
PY  - 2023
DA  - October
DO  - 10.55262/fabadeczacilik.1279777
JF  - Fabad Eczacılık Bilimler Dergisi
JO  - Fabad J Pharm Sci
PB  - FABAD Ankara Eczacılık Bilimleri Derneği
WT  - DergiPark
SN  - 1300-4182
SP  - 561
EP  - 584
VL  - 48
IS  - 3
LA  - en
AB  - A mucoadhesive drug delivery system (MDDS) has been a smart approach to the delivery of drugs at the target site. In MDDS mucus membrane and type of polymer plays an important role in the mucoadhesion phenomenon. To explain the mechanism behind mucoadhesion, various theories have been proposed such as electronic, adsorption, wetting, diffusion, and fracture theory. MDDS has been beneficial to some special patients, preferably pediatric and geriatric. Several challenges such as taste masking, dose determination, dosage form spitting, target delivery, the bioavailability of the drug, adverse drug reaction, toxicity, etc. are faced while developing any delivery system for these special patient populations. Keeping these challenges in mind several researchers have attempted to design and formulate MDDS according to their convenience. The current review focuses on a basic overview of mucoadhesion, various theories of mucoadhesion, and mucoadhesive polymers. The later part of the review focuses on the MDDS for pediatric and geriatric patients with their significance. Various patented formulations and clinical trials going on for these populations have also been discussed.
KW  - mucoadhesive
KW  - pediatric
KW  - geriatric
CR  - Francois M, Snoeckx E, Putteman P, Wouters F, De
Proost E, Delaet U, Peeters J, Brewster ME.,(2003).
A mucoadhesive, cyclodextrin-based vaginal
cream formulation of itraconazole. Aaps Pharmsci.,
5(1):50-4.
CR  - Freerks, L.; Soulou, E.P.; Batchelor, H.; Klein, S.,(
2019). A review of GI conditions critical to oral
drug absorption in malnourished children. Eur.J.
Pharm. Biopharm., 137, 9-22.doi: 10.1016/j.
ejpb.2019.02.001
UR  - https://doi.org/10.55262/fabadeczacilik.1279777
L1  - https://dergipark.org.tr/tr/download/article-file/3070388
ER  -