TY  - JOUR
T1  - Retrospective Analysis of Twenty-Three Thousand Covid-19 Case: A Strong Association with Gender and Age
TT  - Yirmi Üç Bin Covid-19 Olgusunun Retrospektif İncelemesi: Cinsiyet ve Yaşta Güçlü İlişki
AU  - Batı, Serap
AU  - Çetin, İbrahim
PY  - 2025
DA  - April
Y2  - 2025
DO  - 10.25279/sak.1280366
JF  - Health Academy Kastamonu
JO  - HAK
PB  - Esra DEMİRARSLAN
WT  - DergiPark
SN  - 2548-1010
SP  - 1
EP  - 9
VL  - 10
IS  - 1
LA  - en
AB  - Aim: This study aims to examine the association of COVID-19 disease-related need for intubation, hospitalization in the intensive care unit, and mortality rates with age and gender. Methods: After obtaining the necessary permissions, this retrospective descriptive study evaluated a total of 23,239 patients who had PCR tests in a hospital serving in XXX province and received inpatient or outpatient treatment. The SPSS 22.0 package program was used for descriptive and inferential analyses of the electronically collected data. Results: 50.8% of the cases were female, 49.2% were male, and the mean age was 44.05±16.47 years. A strong correlation was found between gender and receiving intensive care services, the need for intubation, and mortality rates. Intensive care, intubation, and mortality rates of men were significantly higher than women (p
KW  - COVİD-19
KW  - Coronavirus
KW  - Turkey.
N2  - Amaç: COVİD-19 hastalığına bağlı olarak ortaya çıkan entübasyon ihtiyacı, yoğun bakıma yatış ve ölüm oranlarının yaş ve cinsiyet faktörleri ile ilişkisinin incelenmesidir. Yöntem: Tanımlayıcı tipteki araştırmada, gerekli izinler alındıktan sonra XXX ilinde hizmet veren bir hastanede PCR testi yaptırmış, hastanede yatan ya da tedavisi ayaktan planlanıp hastane dışı takip edilen 23.239 olgunun retrospektif incelemesi yapılmıştır. Veriler, elektronik ortamda toplanmış olup, tanımlayıcı ve çıkarımsal analizler için SPSS 22.0 paket programı kullanılmıştır. Bulgular: Olguların %50,8’i kadın, %49,2’si erkek ve genel yaş ortalaması 44,05±16,47 olarak tespit edilmiştir. Cinsiyet ile yoğun bakım hizmeti alma, entübasyon gereksinimi ve ölüm oranları arasında güçlü ilişki bulunmuştur. Erkeklerin yoğun bakım hizmeti alma, entübasyon ve ölüm oranları kadınlara göre anlamlı derecede daha yüksektir (p
CR  - Abate, B. B., Kassie, A. M., Kassaw, M. W., Aragie, T. G., &Masresha, S. A. (2020). Sex difference in coronavirus disease (COVID-19): a systematic review and meta-analysis. BMJ open, 10(10), e040129. https://doi.org/10.1136/bmjopen-2020-040129
CR  - Adams, Z. W., Kaiser, A. J., Lynam, D. R., Charnigo, R. J., &Milich, R. (2012). Drinking motives as mediators of the impulsivity-substance use relation: pathways for negative urgency, lack of premeditation, and sensation seeking. Addictive behaviors, 37(7), 848–855. https://doi.org/10.1016/j.addbeh.2012.03.016
CR  - Asem, N., Ramadan, A., Hassany, M., Ghazy, R. M., Abdallah, M., Ibrahim, M., Gamal, E. M., Hassan, S., Kamal, N., & Zaid, H. (2021). Pattern and determinants of COVID-19 infection and mortality across countries: An ecological study. Heliyon, 7(7), e07504. https://doi.org/10.1016/j.heliyon.2021.e07504
CR  - Bergman, J., Ballin, M., Nordström, A., &Nordström, P. (2021). Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study. European journal of epidemiology, 36(3), 287–298. https://doi.org/10.1007/s10654-021-00732-w
CR  - Besch, G., Favier, L., Fiani, M., Ouattara, A., Joannes-Boyau, O., Fischer, M. O., … AZUREA group (2021). French multicentre observational study on SARS-CoV-2 infections intensive care initial management: the FRENCH CORONA study. Anaesthesia, critical care & pain medicine, 40(4), 100931. https://doi.org/10.1016/j.accpm.2021.100931
CR  - Cai H. (2020). Sex difference and smoking predisposition in patients with COVID-19. The Lancet. Respiratory medicine, 8(4), e20. https://doi.org/10.1016/S2213-2600(20)30117-X
CR  - Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet (London, England), 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7
CR  - Chen, T., Wu, D., Chen, H., Yan, W., Yang, D., Chen, G. et al. (2020). Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study, BMJ (Clinical research ed.), 368, m1295. https://doi.org/10.1136/bmj.m1295
CR  - Conway, B. J., Kim, J. W., Brousseau, D. C., & Conroy, M. (2021). Heart Disease, Advanced Age, Minority Race, and Hispanic Ethnicity Are Associated With Mortality in COVID-19 Patients. WMJ : official publication of the State Medical Society of Wisconsin, 120(2), 152–155.
CR  - García-Alvarado, F. J., Muñoz-Hernández, M. A., Moran Guel, E., González-Martínez, M. D. R., Macías Corral, M. A., & Delgado-Aguirre, H. A. (2021). Risk Factors and Clinical Phenotypes Associated with Severity in Patients with COVID-19 in Northeast Mexico. Vector borne and zoonotic diseases (Larchmont, N.Y.), 21(9), 720–726. https://doi.org/10.1089/vbz.2021.0016
CR  - https://COVİD19.saglik.gov.tr/Eklenti/39230/0/COVİD-19-weekly-situation-report43pdf.pdf?_tag1=D3D202441F1F5165A33D16981E6544EF7FC0A32F
https://globalhealth5050.org/COVİD19/, accessed on May 13, 2020
CR  - Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England), 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
CR  - Karcıoğlu, Ö. (2020). COVID-19: Its epidemiology and course in the world. Journal of ADEM, 1(1): S55-S71. https://dergipark.org.tr/tr/pub/jadem/issue/53871/722886#article_cite
CR  - Katikireddi, S. V., Hainey, K. J., & Beale, S. (2021). The impact of COVID-19 on different population subgroups: ethnic, gender and age-related disadvantage. The journal of the Royal College of Physicians of Edinburgh, 51(S1), S40–S46. https://doi.org/10.4997/JRCPE.2021.240
CR  - Klein, S. L., & Flanagan, K. L. (2016). Sex differences in immune responses. Nature reviews. Immunology, 16(10), 626–638. https://doi.org/10.1038/nri.2016.90
CR  - Kline, K., & Bowdish, D. (2016). Infection in an aging population.. Current opinion in microbiology, 29, 63-7 . https://doi.org/10.1016/j.mib.2015.11.003.
CR  - Nasiri, M., Haddadi, S., Tahvildari, A., Farsi, Y., Arbabi, M., Hasanzadeh, S., Jamshidi, P., Murthi, M., & Mirsaeidi, M. (2020). COVID-19 Clinical Characteristics, and Sex-Specific Risk of Mortality: Systematic Review and Meta-Analysis. Frontiers in Medicine, 7. https://doi.org/10.3389/fmed.2020.00459.
CR  - NIPH, https://www.fhi.no/en/id/infectious-diseases/coronavirus/daily-reports/daily-reports-COVİD19/#intensive-care-admissions ErişimTarihi: 02.07.2021
CR  - Peckham, H., De Gruijter, N., Raine, C., Radziszewska, A., Ciurtin, C., Wedderburn, L., Rosser, E., Webb, K., & Deakin, C. (2020). Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nature Communications, 11. https://doi.org/10.1038/s41467-020-19741-6.
CR  - Penna, C., Mercurio, V., Tocchetti, C. G., &Pagliaro, P. (2020). Sex-related differences in COVID-19 lethality. British journal of pharmacology, 177(19), 4375–4385. https://doi.org/10.1111/bph.15207
CR  - Roger, C., Collange, O., Mezzarobba, M., Abou-Arab, O., Teule, L., Garnier, M., Hoffmann, C., Muller, L., Lefrant, J. Y., Guinot, P. G., Novy, E., Abraham, P., Clavier, T., Bourenne, J.,
CR  - Shim, E., Tariq, A., Choi, W., Lee, Y., &Chowell, G. (2020). Transmission potential and severity of COVID-19 in South Korea. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 93, 339–344. https://doi.org/10.1016/j.ijid.2020.03.031.
CR  - Sorci, G., & Faivre, B. (2022). Age-dependent virulence of human pathogens. PLoS Pathogens, 18. https://doi.org/10.1371/journal.ppat.1010866.
CR  - Starke, R., Petereit-Haack, G., Schubert, M., Kämpf, D., Schliebner, A., Hegewald, J., & Seidler, A. (2020). The Age-Related Risk of Severe Outcomes Due to COVID-19 Infection: A Rapid Review, Meta-Analysis, and Meta-Regression. International Journal of Environmental Research and Public Health, 17. https://doi.org/10.3390/ijerph17165974.
CR  - Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., & Peng, Z. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 323(11), 1061–1069. https://doi.org/10.1001/jama.2020.1585
CR  - Wei-jie Guan, Ph.D., Zheng-yi Ni, M.D., Yu Hu, M.D., Wen-hua Liang, Ph.D., Chun-quanOu, Ph.D., Jian-xing He, M.D., Lei Liu, M.D., Hong Shan, M.D., Chun-liang Lei, M.D., David S.C. Hui, M.D., Bin Du, M.D., Lan-juan Li, M.D., et al., for the China Medical Treatment Expert Group for Covid-19 (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine. 382: S1708–S1720. DOI: 10.1056/NEJMoa2002032
CR  - Wong, D. R., Willett, W. C., &Rimm, E. B. (2007). Smoking, hypertension, alcohol consumption, and risk of abdominal aortic aneurysm in men. American journal of epidemiology, 165(7), 838–845. https://doi.org/10.1093/aje/kwk063
CR  - Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England), 395(10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3
CR  - Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., Zheng, X. S., … Shi, Z. L. (2020). Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 588(7836), E6. https://doi.org/10.1038/s41586-020-2951-z
UR  - https://doi.org/10.25279/sak.1280366
L1  - https://dergipark.org.tr/tr/download/article-file/3072875
ER  -