TY  - JOUR
T1  - TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS
TT  - ROTAVİRÜS GASTROENTERİTİNE BAĞLI GEÇİCİ BENİGN HİPERFOSFATAZEMİ
AU  - Çiçek, Muharrem
AU  - Akkuş, Yasin
AU  - Elma, Melek
AU  - Baran Özmen, Selen
AU  - Kalaycık Şengül, Özlem
PY  - 2023
DA  - December
DO  - 10.26650/IUITFD.1281081
JF  - Journal of Istanbul Faculty of Medicine
JO  - İst Tıp Fak Derg
PB  - İstanbul Üniversitesi
WT  - DergiPark
SN  - 1305-6441
SP  - 402
EP  - 405
VL  - 86
IS  - 4
LA  - en
AB  - Transient benign hyperphosphatasemia (TBH) is a benign condition characterized by transiently elevated serum alkaline phosphatase (ALP) levels by 3-50 times normal values. It can sometimes be seen in connection with different clinical disorders such as respiratory tract infections, gastrointestinal diseases, congenital metabolic disorders, malignancies, congenital anomalies, anemia, and neurological disorders. In this report, we describe three children who had TBH after rotavirus-associated gastroenteritis and in whom there was no evidence of liver or bone disease. We aim to raise awareness and draw attention to TBH in this case report.
KW  - Transient hyperphosphatasemia
KW  - alkaline phosphatase
KW  - rotavirus
KW  - gastroenteritis
KW  - children
N2  - Geçici benign hiperfosfatazemi (TBH), serum alkalen fosfataz (ALP) düzeylerinin normalin 3-50 katı kadar geçici olarak yükselmesi ile karakterize ve bazen de gastrointestinal hastalıklar, solunum yolu enfeksiyonları, doğumsal anomaliler, doğumsal metabolik bozukluklar, anemi, maligniteler, nörolojik bozukluklar gibi farklı klinik bozukluklarla birlikte görülebilmektedir. Bu çalışmada, karaciğer veya kemik hastalığı olmayan, rotavirüs ile ilişkili gastroenterit sonrası TBH'li üç çocuk sunuldu. Bu olguların sunulması ile TBH konusuna dikkat çekilmesi ve farkındalık yaratılması amaçlandı.
CR  - 1. Lowe D, Sanvictores T, John S. Alkaline phosphatase. StatPearls Publishing: Treasure Island, FL, USA. 2022. google scholar
CR  - 2. Çiçek G, Özen EU. Karaciğer histolojisi ve embriyolojisi. In: Anılır E, Önal Z, İbrişim D, editors. Hepatoloji. Ankara: Akademisyen Kitabevi; 2020. p. 15-28. google scholar
CR  - 3. Çakır BÇ, Kırsaçlıoğlu CT, Tartıcı EK, Demirel F. Transient hyperphosphatasemia in infants and children: a retrospective study of 43 cases. J Contemp Med 2017;7(2):138-42. [CrossRef] google scholar
CR  - 4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child 1985;139(7):736-40. [CrossRef] google scholar
CR  - 5. Dursun F, Kirmizibekmez H. A case series of benign transient hyperphosphatasemia from a pediatric endocrinology reference health facility in Turkey. Pan African Medical Journal. 2018;30(1). [CrossRef] google scholar
CR  - 6. Banerjee S, Mehta R, Thu M, Narwal S, Moukarzel AA. Rotavirus infection and diarrhea resulting in transient hyperphosphatasemia with no evidence of liver or bone disease. J Pediatr Gastroenterol Nutr 1998;27(4):488. [CrossRef] google scholar
CR  - 7. Erat T, Atar M, Kontbay T. Transient benign hyperphosphatasemia due to COVID-19: the first case report. J Pediatr Endocrinol Metab 2021;34(3):385-7. [CrossRef] google scholar
CR  - 8. Gualco G, Lava SA, Garzoni L, Simonetti GD, Bettinelli A, Milani GP, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr 2013;57(2):167-71. [CrossRef] google scholar
CR  - 9. Behülovâ D, Bzduch V, Holesovâ D, Vasilenkovâ A, Ponec J. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000;46(11):1868-9. [CrossRef] google scholar
CR  - 10. Shkalim Zemer V, Hoshen M, Levinsky Y, Richenberg Y, Yosef N, Oberman B, et al. Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr 2023: 182(7):3211-6. [CrossRef] google scholar
CR  - 11. Suzuki M, Okazaki T, Nagai T, Törö K, Setonyi P Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002;33(3):215-8. [CrossRef] google scholar
CR  - 12. Chu AS, Rothschild JG. Update on benign transient hyperphosphatasemia: recognizing an underappreciated condition. Clin Pediatr. 2016;55(6):564-6. [CrossRef] google scholar
CR  - 13. Huh SY, Feldman HA, Cox JE, Gordon CM. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009;124(2):703-9. [CrossRef] google scholar
CR  - 14. Gallo S, Comeau K, Sharma A, Vanstone CA, Agellon S, Mitchell J, et al. Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada. Clin Biochem 2014;47(15):27-32. [CrossRef] google scholar
CR  - 15. Schonhaut BL, Rocha RA. Benign transient hyperphosphatasaemia in infants: clinical series. Rev Chil Pediatr 2017;88(1):169-75. google scholar
CR  - 16. Ridefelt P, Gustafsson J, Aldrimer M, Hellberg D. Alkaline phosphatase in healthy children: reference intervals and prevalence of elevated levels. Horm Res Paediatr 2014;82(6):399-404. [CrossRef] google scholar
CR  - 17. Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011;24(5-6):351-3. [CrossRef] google scholar
UR  - https://doi.org/10.26650/IUITFD.1281081
L1  - https://dergipark.org.tr/tr/download/article-file/3075779
ER  -