TY  - JOUR
T1  - Antidiabetic and Antioxidant Effects of Bryonia multiflora Boiss. & Heldr. in a Rat Model of Streptozotocin-Induced Diabetes
AU  - Alkan, Elif Ebru
AU  - Çelik, İsmail
AU  - Bati, Bedia
PY  - 2023
DA  - July
DO  - 10.46871/eams.1287621
JF  - Experimental and Applied Medical Science
JO  - Exp Appl Med Sci
PB  - Gaziantep İslam Bilim ve Teknoloji Üniversitesi
WT  - DergiPark
SN  - 2757-847X
SP  - 453
EP  - 476
VL  - 4
IS  - 1
LA  - en
AB  - Objective: This aim of this study is to investigate the antidiabetic, antioxidant and hypolipidemic potential of Bryonia multiflora Boiss. & Heldr. in streptozotocin (STZ) induced diabetes in rats. Material and Methods: During 21 days, control group (NC) and diabetes control (DC) were fed only with food and water, while diabetes acarbose group (DAC) was fed with 20 mg / kg of acarbose.  The DB1, DB2, DB3 groups were fed with 100 mg / kg, 200 mg/kg and 400 mg / kg Bryonia multiflora plant extract, respectively. The body weight and biochemical parameters glucose level, insulin level, glycosylated hemoglobin, total cholesterol, triglyceride, aminotransferase (ALT), lactate dehydrogenase (LDH),  C-peptide,  LDL- cholesterol (LDL-c), HDL-cholesterol (HDL-c), creatinine (CRE), blood urea nitrogen (BUN), urea (Ure) and antioxidant parameters were  examined for all treated groups and compared against diabetic control group and normal control group. Results: Bryonia multiflora (BM) plant extract (100 mg/kg, 200 mg/kg and 400 mg/kg) that administered in respective groups of diabetic animals for 21 days significantly reduced the blood glucose level  and glycosylated hemoglobin ( HbA1c) levels in streptozotocin induced diabetic rats. While the levels of insulin and C-peptide of DC group were found significantly lower (p
KW  - Antidiabetic
KW  - Antioxidant
KW  - Bryonia multiflora
KW  - Diabetes mellitus
KW  - Oxidative stress
KW  - Rats
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UR  - https://doi.org/10.46871/eams.1287621
L1  - https://dergipark.org.tr/tr/download/article-file/3102979
ER  -