TY  - JOUR
T1  - Statine Bağlı Rabdomyoliz Olgusu
TT  - A Case of Statin-Induced Rhabdomyolysis
AU  - Özdemir, Serdar
AU  - Erdil, Fahriye Naz
AU  - Eroğlu, Serkan Emre
PY  - 2023
DA  - August
JF  - Yeni Yüzyıl Journal of Medical Sciences
JO  - JMS
PB  - İstanbul Yeni Yüzyıl Üniversitesi
WT  - DergiPark
SN  - 2687-5411
SP  - 154
EP  - 157
VL  - 4
IS  - 3
LA  - tr
AB  - Statinler hiperlipidemi tedavisinde ilk basamakta tercih edilen ilaçlardandır. Statin tedavisinin iyi bilinen bir yan etkisi olabilen rabdomiyoliz kas hücrelerinde nekroz ve hücre içeriğinin intravenöz alana salınması ile oluşan bir sendromdur. Hastalar miyalji kas güçsüzlüğü koyu renkli idrar yapma şikâyetleri ile başvururlar. İleri yaş, diyabet, hipotiroidizm, polifarmasi ve böbrek yetmezliğinin statin ilişkili rabdomiyoliz riskini arttırdığı bilinmektedir. Tedaviye başlarken hiperlipidemisi olup ek hastalıkları olan ve çoklu ilaç kullanımı olan hastalarda statinlerin ilaç etkileşimleri göz önünde bulundurulmalıdır. Bu olgu sunumunda statinin indüklediği rabdomiyoliz ve bu yan etkinin görülmesindeki olası tetikleyicilere dikkat çekmek amaçlanmıştır.
KW  - statin
KW  - rabdomiyoliz
KW  - acil servis
N2  - Statins are among the drugs of choice in the first-line treatment of hyperlipidemia. Rhabdomyolysis, which can be a well-known side effect of statin therapy, is a syndrome of muscle cell necrosis and release of cell contents into the intravenous area. Patients present with the complaints of myalgia muscle weakness and dark colored urine. It is known that advanced age, diabetes, hypothyroidism, polypharmacy and renal failure increase the risk of statin-associated rhabdomyolysis. When starting treatment, drug interactions of statins should be considered in patients with hyperlipidemia, co-morbidities and multiple drug use. In this case report, it is aimed to draw attention to statin-induced rhabdomyolysis and possible triggers for this side effect.
CR  - 1. Özdemir S, Ocal O, Aksel G. Evaluation of rhabdomyolysis patients who
opted for emergency services. North Clin Istanb. 2017 Oct 20;4(3):257-
261. doi: 10.14744/nci.2017.85619.
CR  - 2. Altunok İ. Novel coronavirus infection and rhabdomyolysis. J. Exp.
Clin. Med.. 2022; 39(2): 593-594.
CR  - 3. Ak R, Doganay F, Ozdemır S, Akoglu EU, Öztürk TC. Excessive cola-based drink consumption as a criminal for hypokalemia and rhabdomyolysis. Marmara Med J. 2016; 29(2): 121-123.
CR  - 4. Özdemir S. Re: A case of acute renal failure requiring emergency hemodialysis due to hypothermia-associated rhabdomyolysis. J Surg Med.
2022; 6(1): 82-83. Doi: 10.28982/josam.953596
CR  - 5. Yıldırım T, Ede H, Özdemir ZT, Börekçi E. Statine Bağlı Rabdomiyoliz:
Olgu Sunumu. Bozok Tıp Dergisi. 2015; 5(2): 75-79.
CR  - 6. Mendes P, Robles PG, Mathur S. Statin-induced rhabdomyolysis: a comprehensive review of case reports. Physiother Can. 2014
Spring;66(2):124-32. doi: 10.3138/ptc.2012-65.
CR  - 7. Safitri N, Alaina MF, Pitaloka DAE, Abdulah R. A Narrative Review of
Statin-Induced Rhabdomyolysis: Molecular Mechanism, Risk Factors,
and Management. Drug Healthc Patient Saf. 2021 Nov 8;13:211-219.
CR  - 8. Eroğlu EÖ, Yildiz Mİ, Yazici MK. Atypical Neuroleptic Malignant Syndrome Induced by Low Dose Quetiapine in a Patient Treated with Donepezil. Noro Psikiyatr Ars. 2021 Jun 3;58(2):166-168. doi: 10.29399/
npa.27421.
CR  - 9. Turner RM, Pirmohamed M. Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and
Muscle Components. J Clin Med. 2019 Dec 20;9(1):22. doi: 10.3390/
jcm9010022.
CR  - 10. März W, Wollschläger H, Klein G, Neiss A, Wehling M. Safety of
low-density lipoprotein cholestrol reduction with atorvastatin versus
simvastatin in a coronary heart disease population (the TARGET TANGIBLE trial). Am J Cardiol. 1999 Jul 1;84(1):7-13. doi: 10.1016/s0002-
9149(99)00183-6.
UR  - https://dergipark.org.tr/tr/pub/yjms/issue//1298618
L1  - https://dergipark.org.tr/tr/download/article-file/3149274
ER  -