TY - JOUR T1 - Effect of Vitamin C on Oxidant and Antioxidant Parameters in Cattle Immunized by Blackleg Vaccine TT - Yanıkara Aşısı ile Aşılanan Sığırlarda C Vitamininin Oksidan ve Antioksidan Parametreler Üzerine Etkisi AU - Doğan, Ertan AU - Merhan, Oğuz AU - Ergin Eğritağ, Hale AU - Bozukluhan, Kadir AU - Erdağ, Dinçer PY - 2023 DA - December DO - 10.53913/aduveterinary.1307606 JF - Animal Health Production and Hygiene JO - Animal Health, Prod and Hyg PB - Aydın Adnan Menderes Üniversitesi WT - DergiPark SN - 2146-7269 SP - 7 EP - 12 VL - 12 IS - 2 LA - en AB - The goal of this study is to determine the effect of vitamin c on certain oxidant and antioxidant parameters in cattle immunized against blackleg. In the study, a total of 40 cattle aged 12 to 18 months, of different breeds and genders, were used in the Ardahan region. The cattle were divided into four equal groups. The Control group received 2 ml of saline, the Vitamin group received 5 mg/kg dose of vitamin c, the Vaccine-Vitamin group received 2 ml of blackleg vaccine and 5mg/kg vitamin c, and the Vaccine group received 2 ml of blackleg vaccine. Blood samples were taken from all animals before vaccination (day 0) and on the 2nd, 14th, and 28th days of administration. On the 2nd, 14th, and 28th days, malondialdehyde (MDA) and nitric oxide (NO) levels were substantially increased (P KW - Blackleg vaccine KW - Cattle KW - Lipid Peroxidation KW - Oxidative stress KW - Vitamin C N2 - Bu araştırmanın amacı Yanıkara aşısı ile aşılanan sığırlarda c vitamininin bazı oksidan ve antioksidan parametreler üzerine etkisini belirlemektir. Araştırmada, Ardahan yöresinde ırk ve cinsiyetleri farklı, 12-18 aylık toplam 40 sığır kullanıldı. Sığırlar dört eşit gruba ayrıldı. Kontrol grubuna 2 ml serum fizyolojik, Vitamin grubuna 5 mg/kg dozda c vitamini, Aşı-Vitamin grubuna 2 ml yanıkara aşısı ve 5mg/kg c vitamini, Aşı grubuna ise 2 ml yanıkara aşısı enjekte edildi. Aşı ve ilaç uygulaması öncesinde (0.gün) ve uygulamanın 2. 14. ve 28. gününde tüm hayvanlardan kan örnekleri alındı. Uygulamanın 2.14. ve 28. gününde Aşı grubunda malondialdehit (MDA) ve nitrik oksit (NO) düzeyinin Kontrol ve Vitamin grubuna göre anlamlı oranda (P CR - Abd Ellah, M.R., Okada, K., Goryo, M., Oishi, A., & Yasuda, J. (2009). Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration. The Veterinary Journal, 182 (2), 336–341. https://doi.org/10.1016/j. tvjl.2008.05.013 CR - Abreu, C.C., Edwards, E.E., Edwards, J.F., Gibbons, P.M., Leal de Araújo, J., Rech, R.R., & Uzal, F.A. (2017). Blackleg in cattle: A case report of fetal infection and a literature review. 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