@article{article_1322881, title={The “Eye of the tiger sign” in Progressive Supranuclear Palsy: Is it a coincidence or not?}, journal={Experimental and Applied Medical Science}, volume={4}, pages={595–600}, year={2024}, DOI={10.46871/eams.1322881}, author={Genç, Hamit and Öksüz, Nevra and Doğu, Okan}, keywords={Progressive supranuclear palsy, the “eye of the tiger” sign, iron accumulation}, abstract={Progressive supranuclear palsy (PSP); is a neurodegenerative disorder involved in atypical parkinsonism syndromes. The classical clinical presentation is postural instability, falls, downward paralysis, frontal dementia, and symmetric akinetic-rigid parkinsonism. The atrophy of the mesencephalon in magnetic resonance imaging (MRI) is an important marker in diagnosing the disease. Recently, a few PSP cases reported the “eye of the tiger” sign on MRI. The “eye of the tiger” sign, in globus pallidus, is a sign that bilaterally symmetrically located low signal intensity and central longitudinal hyperintensity are observed. While previously a specific finding for the pantothenate kinase-associated neurodegeneration (PKAN), it is no longer considered specific because of the reported cases of non-PKAN with the “eye of the tiger” sign such as neuropherritinopathy, multi-system atrophy, corticobasal degeneration. In this report, we aimed to contribute to the literature by presenting two PSP cases in which the “eye of the tiger” sign was observed.}, number={4}, publisher={Gaziantep İslam Bilim ve Teknoloji Üniversitesi}, organization={Yok}