@article{article_1336794, title={Distribution of Macrophages and Plasma Cells in Odontogenic Cysts}, journal={Journal of Contemporary Medicine}, volume={13}, pages={1076–1080}, year={2023}, author={Kaya Korkmaz, Özge and Erdem, Havva and Akçay Çelik, Mürüvvet and Salman, Fadime Gül and Erşan Erdem, Büşra and Kaşko Arıcı, Yeliz}, keywords={Radiküler kist, Odontojenik kist, Makrofaj, Plazma hücresi}, abstract={Abstract Objective : Odontogenic cysts are common and important lesions of the maxillofacial region. Radicular cysts, dentigerous cysts, and odontogenic keratocysts are the most common odontogenic cysts. Macrophages and plasma cells are the main cells of inflammation and play a role in the development of many diseases. This study aimed to compare the presence and distribution of macrophages and plasma cells among the most common odontogenic cysts with clinical data. Method : Cases diagnosed with odontogenic cysts in our laboratory were included in our study. Hematoxylin-Eosin stained sections of the cases in the archive were re-evaluated. The area that best reflected the inflammation tissue was first marked on the slides and then on the blocks. Then, 2 mm diameter cylindrical-shaped paraffinized tissue samples were taken from donor blocks and transferred to multiple blocks with a manual microarray device. Anti-CD68 and anti-CD138 immunohistochemical stains were applied to multiple blocks. The stained preparations were scored between 0-2 by giving an average score. The scores were then analyzed together with clinical data between the three groups. Results: Of the 83 odontogenic cysts included in our study, 41 were radicular cysts, 25 were dentigerous cysts, and 17 were keratocysts. The ages of the patients ranged from 17 to 77 years, with a mean of 37.55± 16.42 years. 47% of the patients were male, and 53% were female. There was no significant difference between the odontogenic cyst groups regarding age and gender (p>0.05). There was a significant difference between the cyst type and the proportions of CD68+ macrophages and CD138+ plasma cells (p <0.05). Conclusion: There was a significant difference in the distribution of CD68+ macrophages and CD138+ plasma cells in odontogenic cyst type. Therefore, it is important to have more information about the histomorphologic features of odontogenic cysts and to understand their inflammatory processes for correct diagnosis and treatment.}, number={6}, publisher={Rabia YILMAZ}, organization={yok}