TY  - JOUR
T1  - Antioxidative Strategy in Traumatic Brain Injury: Role of Low-Molecular-Weight Antioxidants
AU  - Saidu, Umar Faruk
AU  - Bulama, Ibrahim
AU  - Suleiman, Nasiru
AU  - Abbas, Abdullahi
AU  - Saidu, Yusuf
AU  - Yakubu, Yusuf
AU  - Jinjiri, Nasiru
AU  - Bilbis, Lawal
PY  - 2024
DA  - February
DO  - 10.46871/eams.1346139
JF  - Experimental and Applied Medical Science
JO  - Exp Appl Med Sci
PB  - Gaziantep İslam Bilim ve Teknoloji Üniversitesi
WT  - DergiPark
SN  - 2757-847X
SP  - 573
EP  - 594
VL  - 4
IS  - 4
LA  - en
AB  - Objective: Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. This study was designed to investigate the beneficial and neuroprotective role of some Low-Molecular-Weight antioxidants (LMWA) in the treatment of TBI in albino rats.Methods: TBI was induced in adult albino rats using the weight-drop method. A total of 70 Rats was used and were divided into 12 treatment groups, a traumatized non-treated group (TNT) and a Non-traumatized non-treated group  (NTNT). There were 5 rats per group. Each of the treatment groups received 22.5 or 45 mg/kg of dimethyl sulfoxide (DMSO), Alpha Lipoic acid (ALA), Uric acid (UA), vitamin C (VC), vitamin E (VE), or Mannitol. Treatment was started 30 min after the trauma and continued for 21 days. To evaluate the functional outcomes, the modified neurological severity score (mNSS) was calculated. The antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)], and malondialdehyde (MDA) were assayed to evaluate oxidative stress (OS). Results: At 7 days post-TBI, the antioxidant-treated groups exhibited significant (p
KW  - Traumatic brain injury
KW  - Oxidative Stress
KW  - Neurological score
KW  - Low-Molecular-Weight Antioxidants
KW  - Malondialdehyde
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UR  - https://doi.org/10.46871/eams.1346139
L1  - https://dergipark.org.tr/tr/download/article-file/3345808
ER  -