TY  - JOUR
T1  - Relationship Between Triglyceride-Glucose Index and Microvascular Complications in Hospitalized Patients with Type 2 Diabetes Mellitus
TT  - Hastanemizde Yatan Tip 2 Diyabetli Hastalarda Trigliserid/Glukoz İndeksi ile Diyabetin Mikrovasküler Komplikasyonları Arasındaki İlişki
AU  - Fakı, Sevgül
AU  - Tam, Abbas Ali
AU  - İnce, Nurcan
AU  - Altay, Feride Pınar
AU  - Karaahmetli, Gülsüm
AU  - Housseın, Mehdi
AU  - Topaloğlu, Oya
AU  - Ersoy, Reyhan
AU  - Çakır, Bekir
PY  - 2024
DA  - April
Y2  - 2024
DO  - 10.25048/tudod.1359840
JF  - Turkish Journal of Diabetes and Obesity
JO  - Turk J Diab Obes
PB  - Zonguldak Bülent Ecevit Üniversitesi
WT  - DergiPark
SN  - 2587-0335
SP  - 13
EP  - 18
VL  - 8
IS  - 1
LA  - en
AB  - Aim: The increasing prevalence of diabetes mellitus (DM) brings about a rise in nephropathy, retinopathy, and neuropathy, whichare microvascular complications of diabetes. The triglyceride-glucose (TyG) index is a convenient indicator of insulin resistance. It isrelated to microvascular and macrovascular complications among nonhospitalized patients with diabetes. However, it is unclear if theTyG index poses risks for vascular complications of type 2 DM in hospitalized patients. This study aims to investigate possible relationsbetween this index and the risk of microvascular complications in hospitalized patients with type 2 DM.Material and Methods: The present study included 420 type 2 DM patients who were hospitalized in our clinic between February 2019and May 2022. The TyG index was measured as fasting triglycerides mg/dL × fasting glucose mg/dL/2. The presence of microalbuminuria(MAU), diabetic neuropathy, chronic kidney disease (CKD), and retinopathy (DR) were evaluated. The data were analzed using IBMSPSS 22.0 statistical software. The level of statistical significance was taken as p
KW  - Triglyceride-glucose index
KW  - diabetic retinopathy
KW  - diabetic nephropathy
KW  - diabetic neuropathy
N2  - Amaç: Diyabetes melitusun (DM) prevalansındaki artış, diyabete bağlı mikrovasküler (nefropati, retinopati ve nöropati)komplikasyonların artışını da beraberinde getirmektedir. Trigliserid/glukoz indeksi (TyG) insülin direncini yansıtmakta kullanışlı birgöstergedir. Ayakta tedavi alan diyabetli hastalarda mikrovasküler ve makrovasküler komplikasyonlar ile arasındaki ilişki gösterilmiştir.Ancak yatan hastalarda bu ilişki net değildir. Hospitalize olan tip 2 diyabetli hastalarda trigliserid/glukoz indeksi ile diyabetinmikrovasküler komplikasyonları arasındaki olası ilişkiyi araştırmayı amaçladık.Gereç ve Yöntemler: Bu çalışmaya Şubat 2019-Mayıs 2022 tarihleri arasında tip 2 DM nedeniyle yatırılan toplam 420 hasta dahil edildi.Trigliserid/glukoz indeksi açlık trigliserid mg/dl × açlık glukoz mg/dl/2 formülüne göre hesaplandı. Her bir hasta için mikroalbuminüri, kronik böbrek hastalığı (KBH), diyabetik nöropati ve retinopati (DR) varlığı değerlendirildi. Verilerin analizinde IBM SPSS 22 yazılımıkullanıldı. Anlamlılık değeri p
CR  - 1. Seid MA, Akalu Y, Gela YY, Belsti Y, Diress M, Fekadu SA,
Dagnew B, Getnet M. Microvascular complications and its
predictors among type 2 diabetes mellitus patients at Dessie
town hospitals, Ethiopia. Diabetol Metab Syndr. 2021;13(1):86.
CR  - 2. Zou J, Tian F, Zhang Y, Li Z, Yang C, Chen H, Zhai J, Shi M,
Xu C, Zhang J, Li W, Xie Y, Li X. Association between Thyroid
Hormone Levels and Diabetic Kidney Disease in Euthyroid
Patients with Type 2 Diabetes. Sci Rep. 2018;8(1):4728.
CR  - 3. Zou J, Li Z, Tian F, Zhang Y, Xu C, Zhai J, Shi M, Wu G, Zhang
Z, Yang C, Chen H, Li. X Association between normal thyroid
hormones and diabetic retinopathy in patients with type 2 diabetes.
Biomed Res Int. 2020;2020:8161797.
CR  - 4. Myron AB, Matthew V. Diabetic neuropathy. StatPearls [Internet].
Treasure Island (FL): StatPearls Publishing; 2018 Jan.
CR  - 5. Pan Y, Zhong S, Zhou K, Tian Z, Chen F, Liu Z, Geng Z, Li
S, Huang R, Wang H, Zou W, Hu J. Association between Diabetes
Complications and the Triglyceride-Glucose Index in
Hospitalized Patients with Type 2 Diabetes. J Diabetes Res.
2021;2021:8757996.
CR  - 6. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher
DF, Turner RC. Homeostasis model assessment: insulin resistance
and beta-cell function from fasting plasma glucose and
insulin concentrations in man. Diabetologia. 1985;28(7):412-
419.
CR  - 7. Kang B, Yang Y, Lee EY, Yang HK, Kim HS, Lim SY, Lee JH,
Lee SS, Suh BK, Yoon KH. Triglycerides/glucose index is a
useful surrogate marker of insulin resistance among adolescents.
Int J Obes (Lond). 2017;41(5):789-792.
CR  - 8. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz
M, Martínez-Abundis E, Ramos-Zavala MG, Hernández-
González SO, Jacques-Camarena O, Rodríguez-Morán M.
The product of triglycerides and glucose, a simple measure of
insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic
clamp. J Clin Endocrinol Metab. 2010;95(7):3347-
3351.
CR  - 9. Liu L, Xia R, Song X, Zhang B, He W, Zhou X, Li S, Yuan G.
Association between the triglyceride-glucose index and diabetic
nephropathy in patients with type 2 diabetes: A cross-sectional
study. J Diabetes Investig. 2021;12(4):557-565.
CR  - 10. Unger G, Benozzi SF, Perruzza F, Pennacchiotti GL. Triglycerides
and glucose index: a useful indicator of insulin resistance.
Endocrinol Nutr. 2014;61(10):533-540.
CR  - 11. Srinivasan S, Singh P, Kulothungan V, Sharma T, Raman R.
Relationship between triglyceride glucose index, retinopathy
and nephropathy in Type 2 diabetes. Endocrinol Diabetes Metab.
2020;4(1):e00151.
CR  - 12. Kwai NCG, Nigole W, M Poynten A, Brown C, V Krishnan
A. The relationship between dyslipidemia and acute axonal
function in Type 2 diabetes mellitus In Vivo. PLoS ONE.
2016;11(4):e0153389.
CR  - 13. Akbar M, Bhandari U, Habib A, Ahmad R. Potential Association
of Triglyceride Glucose Index with Cardiac Autonomic
Neuropathy in Type 2 Diabetes Mellitus Patients. J Korean
Med Sci. 2017;32(7):1131-1138.
CR  - 14. Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, Teliewubai J, Zhang
Y, Xu Y. Association between macro- and microvascular damage
and the triglyceride glucose index in community-dwelling
elderly individuals: the Northern Shanghai Study. Cardiovasc
Diabetol. 2019;18(1):95.
UR  - https://doi.org/10.25048/tudod.1359840
L1  - http://dergipark.org.tr/tr/download/article-file/3405995
ER  -