@article{article_1365883, title={THE RELATION OF SERUM NESFATIN-1 LEVELS WITH DISEASE SEVERITY AND COMPLICATIONS IN PATIENTS WITH LIVER CIRRHOSIS}, journal={Journal of Istanbul Faculty of Medicine}, volume={87}, pages={209–214}, year={2024}, DOI={10.26650/IUITFD.1365883}, author={Kandemir Alibakan, Özlem and Eruzun, Hasan and Toprak, İlkim Deniz and Yılmaz, Uğur and Acar, Mehmet Alptekin and Aslan, İpek Bilge and Polat Onmaz, Merve and Gökden, Yasemin and Arman, Yücel and Tükek, Tufan}, keywords={Nesfatin-1, karaciğer, siroz, dekompansas yon, antienflamatuvar, antioksidan}, abstract={Objective: Nesfatin-1 is an anorectic polypeptide that plays im portant roles in regulating appetite and energy intake. Cachexia and malnutrition are common in individuals with cirrhosis. We ex amined the relationship between serum nesfatin-1 levels and stage of cirrhosis, with the hypothesis that an increase in nesfatin-1 levels in patients with cirrhosis may be related to this catabolic process.
Material and Method: The study includes 51 patients with cirrhosis and 30 healthy volunteers. Nesfatin-1 levels in serum samples were compared using the enzyme-linked immunosorbent assay (ELISA). We calculated the Child-Pugh stages and Model for End-Stage Liver Disease (MELD) scores of patients with cirrhosis and examined their relationship with nesfatin-1. We’ve also investigated the relationship between cirrhosis complications and nesfatin-1.
Results: We found nesfatin-1 levels to be significantly higher in the cirrhosis patient group compared to the control group (p=0.001). The patient group was divided into those with compensated and those with decompensated liver cirrhosis and compared with the control group. Nesfatin-1 levels were found to be significantly higher in the compensated liver cirrhosis group (p=0.01). When classifying the patients with cirrhosis based on their Child-Pugh stages and MELD scores, no significant relationship was detected between these groups and their nesfatin-1 levels.
Conclusion: Nesfatin-1 may have antioxidant, anti-inflammatory, and anti-apoptotic effects in maintaining the state of patients with compensated liver cirrhosis. Low levels of nesfatin-1 in decompensated liver cirrhosis may result from defense mecha nisms and inadequate production.}, number={3}, publisher={İstanbul Üniversitesi}