TY  - JOUR
T1  - Deneysel Şizofreni Modelinde Bilişsel Fonksiyonlar ve Hipokampal Sinaptofizin Düzeylerinin İncelenmesi
TT  - Examination of Cognitive Functions and Hippocampal Synaptophysin Levels in an Experimental Schizophrenia Model
AU  - Eray Çamlı, Şafak
AU  - Ermiş, Erkan
AU  - Koç, Cansu
AU  - Mergen, Hilmiye Şule
AU  - Makinecioğlu, İbrahim
AU  - Vural, Ayşe Pınar
AU  - Cansev, Mehmet
AU  - Göktalay, Gökhan
PY  - 2023
DA  - December
Y2  - 2023
DO  - 10.32708/uutfd.1381823
JF  - Journal of Uludağ University Medical Faculty
JO  - Uludağ Tıp Derg
PB  - Bursa Uludağ Üniversitesi
WT  - DergiPark
SN  - 1300-414X
SP  - 367
EP  - 373
VL  - 49
IS  - 3
LA  - tr
AB  - Şizofreni pozitif, negatif ve bilişsel belirtiler ile seyreden kronik bir beyin hastalığıdır. Bilişsel belirtiler hastalığın prodromal döneminden itibaren gözlenebilmektedir. Bu çalışmanın amacı irkilme refleksininin ön uyaran aracılı inhibisyonu (ÖUAİ) ile oluşturulan deneysel şizofreni modelinde sıçanların bilişsel fonksiyonlarını ve hipokampal presinaptik proteinlerden sinaptofizin düzeylerini araştırmaktır. Çalışmada 30 adet erkek Wistar türü sıçanlar bazal ÖUAİ ölçümüne tabi tutulmuş ve bu değerlere göre düşükten yükseğe sıralanmıştır. İlk 10 sıçan “düşük” ve son 10 sıçan “yüksek” inhibisyonlu grup olarak ayrıldıktan sonra 5 gün boyunca Morris Su Tankı (MST) testine tabi tutulmuştur. Testin bitiminde sıçanlar sakrifiye edilerek hipokampus bölgeleri eksize edilmiş ve hipokampal presinaptik proteinlerden sinaptofizin Western Blot yöntemiyle analiz edilmiştir. Sonuçlara göre her iki grubun öğrenme düzeyleri arasında fark bulunmaz iken ve hafıza fonksiyonlarının platform alanından geçme sıklığı (p
KW  - Şizofreni
KW  - Ön Uyaran Aracılı İnhibisyon
KW  - Endofenotip
KW  - Sinaptofizin
KW  - Hafıza
N2  - Schizophrenia is a chronic brain disease and is clinically characterized by positive, negative and cognitive symptoms. Cognitive symptoms can be observed starting from the prodromal period of the disease. The aim of this study is to investigate the cognitive functions of rats and hippocampal levels of the presynaptic protein synaptophysin in an experimental schizophrenia model created by prepulse-mediated inhibition (PPI) of the startle reflex. In the study, 30 male Wistar type rats were subjected to basal PPI measurements and were ranked from low to high according to these values. After the first 10 rats were divided into the "low" and the last 10 rats into the "high" inhibition group, they were subjected to the Morris Water Maze (MWM) test for 5 days. At the end of the test, the rats were sacrificed, hippocampus regions were excised, and the presynaptic synaptophysin protein was analyzed by Western Blot method. According to the results, while there was no difference between the learning levels of both groups, the frequency of memory functions frequency to cross the platform area (p
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UR  - https://doi.org/10.32708/uutfd.1381823
L1  - https://dergipark.org.tr/tr/download/article-file/3499161
ER  -