TY  - JOUR
T1  - İmmünglobülin G4 İlişkili Hastalık: 30 Vakalık Tek Merkez Deneyimi
TT  - Immunoglobulin G4-Related Disease: A Single Centre Experience of 30 Cases
AU  - Mısırcı, Salim
AU  - Ekin, Ali
AU  - Coşkun, Belkıs Nihan
AU  - Yağız, Burcu
AU  - Dalkılıç, Hüseyin Ediz
AU  - Pehlivan, Yavuz
PY  - 2023
DA  - December
Y2  - 2023
DO  - 10.32708/uutfd.1385438
JF  - Journal of Uludağ University Medical Faculty
JO  - Uludağ Tıp Derg
PB  - Bursa Uludağ Üniversitesi
WT  - DergiPark
SN  - 1300-414X
SP  - 389
EP  - 395
VL  - 49
IS  - 3
LA  - tr
AB  - İmmünglobülin G4 ilişkili hastalık (IgG4-İH) tanısıyla takip ettiğimiz hastaların klinik, demografik ve laboratuvar özelliklerini, tutulum yerlerini, medikal tedavileri ve nüksle ilişkili faktörleri değerlendirmeyi planladık. Üçüncü basamak romatoloji kliniğinde Ağustos 2013-Ağustos 2023 tarihleri arasında IgG4-İH tanısıyla takip edilen, 30 hasta restrospektif olarak tarandı. Hastaların yaş ortalaması 49,5±13,2 olup, çoğunluğunu (n=16, %53,3) erkek hastalar oluşturmaktaydı. Takip süresi ortalama 25 aydı. Eritrosit sedimentasyon hızı hastaların %73,3 (n=22)’ünde, C-reaktif protein ise %66,7 (n=20)’sinde yüksekti. İmmünglobülin G4 (IgG4) düzeyleri sadece 10 (%33,3) hastada yüksek olarak saptandı. En sık retroperitoneal tutulum (n=12,%40) olup, lakrimal veya tükürük bezi tutulumu (n=11,% 36,7) ise ikinci en sık tutulan bölgeydi. Testis tutulumu olup tedavisiz takip edilen bir hasta dışında diğer 29 (%96,7) hastanın tamamında glukokortikoid (GK) kullanımı mevcuttu. En sık kullanılan immünsupresif tedavi ajanı azatiyoprin (n=13, %43,3) olup, rituksimab (n=10, %33,3) ise en sık kullanılan biyolojik hastalık modifiye edici antiromatizmal ilaçtı. On bir (%36,7) hastamızda nüks nedeniyle tedavi değişikliği yapılmıştı. Takip süresinin (Odds oranı=1,040; %95 güven aralığı=1,006-1,075; p
KW  - glukokortikoid
KW  - immünglobülin G4 ilişkili hastalık
KW  - immünsupresif tedavi
KW  - rituksimab
N2  - We aimed to investigate the clinical, demographic, and laboratory characteristics, sites of disease onset, medical treatments, and factors associated with relapse in patients with immunoglobulin G4-related disease (IgG4-RD). Thirty patients with IgG4-RD treated at the tertiary rheumatology clinic between August 2013 and August 2023 were retrospectively reviewed. The mean age of the patients was 49.5±13.2 years and the majority (n=16, 53.3%) were male. The mean follow-up time was 25 months. Erythrocyte sedimentation rate was elevated in 73.3% (n=22) and C-reactive protein in 66.7% (n=20) of patients. Elevated immunoglobulin G4 (IgG4) levels were detected in only 10 (33.3%) patients. Retroperitoneal involvement was the most common site (n=12, 40%) and lacrimal or salivary gland involvement (n=11, 36.7%) was the second most common site. Glucocorticoids (GC) were used in all 29 (96.7%) patients, except for one patient with testicular involvement who was followed up without treatment. The most commonly used immunosuppressive agent was azathioprine (n=13, 43.3%) and rituximab (n=10, 33.3%) was the most commonly used biologic disease-modifying antirheumatic drug. Treatment was changed in eleven (36.7%) patients due to relapse. Prolongation of follow-up (odds ratio=1.040; 95% confidence interval=1.006-1.075; p
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UR  - https://doi.org/10.32708/uutfd.1385438
L1  - https://dergipark.org.tr/tr/download/article-file/3514079
ER  -