@article{article_1385707, title={LIQUID AND SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) CONTAINING VALSARTAN: STABILITY ASSESSMENT AND PERMEABILITY STUDIES}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={48}, pages={525–534}, year={2024}, DOI={10.33483/jfpau.1385707}, author={Yıldız Türkyılmaz, Gülbeyaz and Diril, Mine and Gülmezoğlu, Eda and Karasulu, Yesim}, keywords={Caco-2 hücre hattı, kendi kendine emülsifiye olan ilaç dağıtım sistemleri, katılaştırılmış kendi kendine emülsifiye olan ilaç dağıtım sistemleri, permeabilite, valsartan}, abstract={Objective: Valsartan (VST) is a Biopharmaceutical classification system (BSC) class II active ingredient with a bioavailability of approximately 25% and is utilized to treat high blood pressure (hypertension). This study aimed was to showcase the stability and increase the permeability of VST by developing self-emulsifying drug delivery systems (SEDDS) and solidified SEDDS (S-SEDDS) formulations.
Material and Method: The ratios of the components were determined by the pseudo-ternary phase diagram, and the characterization studies were conducted in the previous study. Stability was performed in long-term (25±2˚C, 60±5% relative humidity) and accelerated (40±2˚C, 75±5% relative humidity) conditions. The intestinal permeability of SEDDS formulations was evaluated by Caco-2 cells.
Result and Discussion: Formulations for 12 month, droplet sizes were found to be 67.52 ± 5.26 nm and 176.93 ± 17.34 nm for SEDDS of VST (VST-SEDDS) and S-SEDDS of VST (VST-S-SEDDS), respectively. During this period, polydispersity indexes were: VST-SEDDS, 0.56±0.1; VST-S-SEDDS, 0.58±0.05. Both formulations increased VST permeability across Caco-2 cells: VST-SEDDS by 2.32x (powder) and 2.18x (commercial); VST-S-SEDDS by 1.38x (powder) and 1.30x (commercial). The formulation components did not have cytotoxic effects. These results demonstrated that newly developed VST-SEDDS and VST-S-SEDDS formulations with high permeability may be a desirable approach for antihypertensive therapy.}, number={2}, publisher={Ankara Üniversitesi}, organization={This study was supported by The Scientific and Technological Council of Turkey (TUBİTAK Project No: 117S821).}