TY - JOUR T1 - The Role of Vitamin D Supplementation Program on Fertility Outcomes in Women with Embryo Transfers TT - Embriyo Transferi Yapılan Kadınlarda D Vitamini Destek Programının Doğurganlık Sonuçları Üzerindeki Rolü AU - Yavaş, Gamze AU - Özekinci, Murat AU - Boz, İlkay AU - Sakıncı, Mehmet PY - 2025 DA - May Y2 - 2024 DO - 10.53394/akd.1390776 JF - Akdeniz Tıp Dergisi JO - Akd Tıp D PB - Akdeniz Üniversitesi WT - DergiPark SN - 2687-2781 SP - 164 EP - 171 VL - 11 IS - 2 LA - en AB - Objective: This study aimed to determine the effect of vitamin D supplementation given to women undergoing embryo transfer on pregnancy outcomes.Materials and Methods: This study was conducted experimentally in a pre-test-post-test design. The sample of the study consisted of a total of 118 women, with 58 in the intervention group and 60 in the control group. While the vitamin D supplementation program was administered to women in the intervention group at the beginning of infertility treatment, women in the control group did not receive a vitamin D supplementation program. At the end of the study, pregnancy and clinical pregnancy rates of women in the intervention and control groups, as well as their serum 25(OH) D levels, were examined.Results: The vitamin D level of women in the intervention group at the beginning of treatment (12.47±6.03 ng/mL) was statistically significantly lower than the vitamin D level on the day of beta-hCG (32.34±9.62 ng/mL) (p=0.000). The mean vitamin D level of the women in the control group (14.30±7.03 ng/mL) on the day of beta-hCG was statistically significantly lower than that of the women in the intervention group (32.34±9.62 ng/mL) (p=0.000). While there was no statistically significant difference in the pregnancy rates of women in the intervention and control groups, a statistically significant difference was found in the clinical pregnancy rates (respectively, p=0.066 and p=0.014).Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer. KW - Embryo transfer KW - infertility KW - pregnancy rate KW - Turkey KW - vitamin D deficiency N2 - Amaç: Bu çalışma embriyo transferi yapılan kadınlara verilen D vitamini desteğinin, gebelik sonuçları üzerindeki etkisini belirlemeyi amaçlamaktadır.Gereç ve Yöntemler: Bu çalışma ön test-son test düzeninde deneysel olarak yürütülmüştür. Çalışmanın örneklemi 58’i girişim, 60’ı kontrol grubunda olmak üzere toplam 118 kadından oluşmaktadır. Girişim grubundaki kadınlara infertilite tedavisinin başlangıcında D vitamini destek programı uygulanırken, kontrol grubundaki kadınlara D vitamini destek programı uygulanmamıştır. Çalışmanın sonunda, girişim ve kontrol grubundaki kadınların gebelik ve klinik gebelik oranları ve kanda 25(OH)D düzeyleri incelenmiştir.Bulgular: Girişim grubundaki kadınların tedavi başlangıcındaki D vitamini düzeyi (12,47±6,03 ng/mL), beta-hCG günü bakılan D vitamin düzeyinden (32,34±9,62 ng/mL) istatistiksel olarak anlamlı düzeyde daha düşüktür (p=0,000). Kontrol grubundaki kadınların beta-hCG günü bakılan D vitamini düzeyi (14,30±7,03 ng/mL), girişim grubundaki kadınlardan (32,34±9,62 ng/mL) istatistiksel olarak anlamlı derecede daha düşüktür (p=0,000). Girişim ve kontrol grubundaki kadınların gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmazken, klinik gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmuştur (p=0,066, p=0,014 sırasıyla).Sonuç: Bu çalışma, infertilite tedavisi gören ve D vitamini düzeyi eksik ya da yetersiz olan kadınlara yönelik D vitamini destek programının, kadınların D vitamini düzeylerini ve embriyo transferi sonrası klinik gebelik oranlarını artırabileceğini göstermiştir. CR - 1. Down J, Stafford D. The Vitamin D cure revised edition. Canada: John Wiley & Sons; 2012. CR - 2. Lauretani F, Maggio M, Ruggiero C, Ceda GP, Ferrucci L. Vitamin D in health of seniors. In: Watson RR, editors. Handbook of Vitamin D in human health. Netherlands: Wageningen Academic Publishers; 2013. CR - 3. Grzechocinska B, Dabrowski FA, Cyganek A, Wielgos M. The role of vitamin D in impaired fertility treatment. Neuro Endocrinol Lett 2013; 34(8):756-62. CR - 4. 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UR - https://doi.org/10.53394/akd.1390776 L1 - https://dergipark.org.tr/tr/download/article-file/3537300 ER -