TY  - JOUR
T1  - Investigating the Influence of Tutukon and Alfuzosin on Stone Expulsion After Retrograde Intrarenal Surgery
TT  - Tutukon ve Alfuzosin’in Retrograd İntrarenal Cerrahi Sonrası Taş Ekspulsiyonu Etkisinin Araştırılması
AU  - Öztürk, Mehmet
AU  - Baturu, Muharrem
AU  - Bayrak, Ömer
AU  - Sevim, Özcan
AU  - Şen, Haluk
AU  - Seçkiner, İlker
PY  - 2024
DA  - January
Y2  - 2024
DO  - 10.54233/endourologybull-1390903
JF  - Endoüroloji Bülteni
JO  - Endourol Bull
PB  - Endoüroloji Derneği
WT  - DergiPark
SN  - 2148-0532
SP  - 8
EP  - 16
VL  - 16
IS  - 1
LA  - en
AB  - Objective: To compare the effects of an alpha-blocker (alfuzosin) versus a herbal agent, “Tutukon®,» on stone-free rates in patients who underwent retrograde intrarenal surgery (RIRS). Material and Methods: We evaluated seventy-five patients who underwent RIRS prospectively consecutively and reported retrospectively between January 2020 and June 2020. Patients were divided into three groups to analyze the effect of medications on stone-free rates after RIRS. “Tutukon®» was prescribed to the first group, alfuzosin 10 mg to the second group, and only dexketoprofen to the third group as the control group. The patients were re-evaluated for stone-free rates after the fourth week of surgery. Results: Among the groups (Tutukon®/Alfuzosin/Control), no differences were observed in terms of age (44.4±15.71/43.16±14.05/46.00±14.43), stone size, stone location and extracorporealshock wave lithotripsy (ESWL) history (p>0.05). Complete stone-free rates at the fourth postoperative week; Group 1 (Tutukon®) was 96%, group 2 (alfuzosin) 84%, and group 3 (control) 76% (p=0.163), and the stone-free rate in Group 1 was significantly higher than that in the control group (Group 1 vs. 3; p= 0.044, Group 2 vs. 3; p=0.363). Evaluation of completely stone-free patients and patients with clinically insignificant residual stones showed no difference between the groups (p=0.234). Conclusion: The data obtained from the use of Tutukon® have similar results to the use of alfuzosin in medical expulsive therapy, suggesting that it may be a preferred phytotherapy method for fragment expulsion after endoscopic stone surgery.
KW  - Medical expulsive treatment
KW  - urolithiasis
KW  - herbal agent
KW  - alfa blocker
KW  - and retrograde intrarenal surgery
N2  - Amaç: Retrograd intrarenal cerrahi (RIRC) uygulanan hastalarda bir alfa-bloker (alfuzosin) ile bitkisel bir ajan olan “Tutukon®»un taşsızlık oranları üzerindeki etkilerini karşılaştırmak.Gereç ve Yöntemler: Ocak 2020 ve Haziran 2020 tarihleri arasında RIRC uygulanan yetmiş beş hasta prospektif olarak değerlendirildi ve retrospektif olarak raporlandı. RIRC sonrası ilaçların taşsızlık oranları üzerindeki etkisini analiz etmek için hastalar üç gruba ayrıldı. Birinci gruba “Tutukon®», ikinci gruba alfuzosin 10 mg ve üçüncü gruba kontrol grubu olarak sadece deksketoprofen reçete edilmiştir. Hastalar ameliyatın dördüncü haftasından sonra taşsızlık oranları açısından tekrar değerlendirildi.Bulgular: Gruplar (Tutukon®/Alfuzosin/Kontrol) arasında yaş (44.4 ±3.14/43.16 ±2.81/46.00±2.88), taş boyutu, taşın yeri ve ekstrakorporeal şok dalga litotripsi (ESWL) öyküsü açısından fark gözlenmedi (p>0.05). Ameliyat sonrası dördüncü haftada tam taşsızlık oranları; Grup 1 (Tutukon®) %96, grup 2 (alfuzosin) %84 ve grup 3 (kontrol) %76 (p=0.163) olup, Grup 1’deki taşsızlık oranı kontrol grubuna göre anlamlı derecede yüksekti (Grup 1 vs. 3; p= 0.044, Grup 2 vs. 3; p=0.363). Tamamen taşsız hastalar ve klinik olarak önemsiz rezidüel taşları olan hastalar değerlendirildiğinde gruplar arasında fark saptanmadı (p=0.234).Sonuç: Tutukon® kullanımından elde edilen veriler, alfuzosinin tıbbi eksülsif tedavide kullanımına benzer sonuçlara sahip olup, endoskopik taş cerrahisi sonrası fragman atılmasında tercih edilebilecek bir fitoterapi yöntemi olabileceğini düşündürmektedir.
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UR  - https://doi.org/10.54233/endourologybull-1390903
L1  - https://dergipark.org.tr/tr/download/article-file/3537830
ER  -