TY - JOUR T1 - A Case of Hypertriglyceridemic Pancreatitis Secondary to Tacrolimus and Estradiol Use for in Vitro Fertilization TT - İn Vitro Fertilization Amaçlı Takrolimus ve Estradiol Kullanımına Sekonder Hipertrigliseridemik Pankreatit Olgusu AU - Civan, Merve AU - Ozan, Ramazan AU - Demiray, Alparslan AU - Koçyiğit, İsmail PY - 2024 DA - April Y2 - 2024 DO - 10.55694/jamer.1400753 JF - Journal of Anatolian Medical Research JO - JAMER PB - Kayseri Şehir Eğitim ve Araştırma Hastanesi WT - DergiPark SN - 2587-1153 SP - 30 EP - 32 VL - 9 IS - 1 LA - en AB - Hypertriglyceridemia is a metabolic condition with multifactorial etiology that may cause life-threatening complications, such as pancreatitis. In pregnant women, hypertriglyceridemia may be secondary to physiological changes during pregnancy or may be exacerbated by medications. The combination of tacrolimus and estradiol is sometimes used in in vitro fertilization (IVF) for women with a history of recurrent implantation failure. This case report discusses a case of acute pancreatitis caused by hypertriglyceridemia secondary to the use of tacrolimus and estradiol. KW - Tacrolimus KW - estradiol KW - in vitro fertilization KW - hypertriglyceridemia KW - pancreatitis N2 - Hipertigliseridemi, pankreatit gibi yaşamı tehdit eden komplikasyonlara neden olabilen çoklu etiyolojiye sahip bir metabolik durumdur. Hamile kadınlarda hipertigliseridemi, gebelik sırasındaki fizyolojik değişikliklere sekonder olabilir veya ilaçlar tarafından kötüleştirilebilir. Tacrolimus ve östradiol kombinasyonu, tekrarlayan implantasyon başarısızlığı öyküsü olan kadınların in vitro fertilizasyon (IVF) tedavisinde kullanılmaktadır. Bu vaka raporu, tacrolimus ve östradiol kullanımına bağlı gelişen hipertigliseridemiye sekonder akut pankreatit vakasını ele almaktadır. CR - Montgomery WH, Miller FC. Pancreatitis and pregnancy. Obstet Gynecol. 1970;35(4):658-664. CR - Bahrami-Asl Z, Farzadi L, Fattahi A, Yousefi M, Quinonero A, Hakimi P, et al. Tacrolimus improves the implantation rate in patients with elevated Th1/2 helper cell ratio and repeated implantation failure (RIF). Geburtshilfe Frauenheilkd. 2020;80(8):851-862. CR - Florêncio RS, Meira MSB, Cunha MVD, Camarço MNCR, Castro EC, Finotti MCCF, et al. Plasmatic estradiol concentration in the mid-luteal phase is a good prognostic factor for clinical and ongoing pregnancies, during stimulated cycles of in vitro fertilization. JBRA Assist Reprod. 2018;22(1):8-14. CR - Sanada M, Tsuda M, Kodama I, Sakashita T, Nakagawa H, Ohama K. Substitution of transdermal estradiol during oral estrogen-progestin therapy in postmenopausal women: effects on hypertriglyceridemia. Menopause (New York, NY). 2004;11(3):331-336. CR - Tory R, Sachs-Barrable K, Goshko CB, Hill JS, Wasan KM. Tacrolimus-induced elevation in plasma triglyceride concentrations after administration to renal transplant patients is partially due to a decrease in lipoprotein lipase activity and plasma concentrations. Transplantation. 2009;88(1):62-68. CR - Gupta M, Liti B, Barrett C, Thompson PD, Fernandez AB. Prevention and management of hypertriglyceridemia-induced acute pancreatitis during pregnancy: A systematic review. Am J Med. 2022;135(6):709-714. CR - Simons-Linares CR, Elkhouly MA, Salazar MJ. DrugInduced Acute Pancreatitis in Adults: An Update. Pancreas. 2019;48(10):1263-1273. CR - Eddy JJ, Gideonsen MD, Song JY, Grobman WA, O’Halloran P. Pancreatitis in pregnancy. Obstet Gynecol. 2008;112(5):1075-1081. CR - Li HY, Li B, Wei YG, Yan LN, Wen TF, Zhao JC, et al. Higher tacrolimus blood concentration is related to hyperlipidemia in living donor liver transplantation recipients. Dig Dis Sci. 2012;57(1):204-209. CR - Liu XH, Chen H, Tan RY, Luo C. Acute pancreatitis due to tacrolimus in kidney transplant and review of the literature. J Clin Pharm Ther. 2021 Feb;46(1):230-235. CR - Aljenedil S, Hegele RA, Genest J, Awan Z. Estrogen-associated severe hypertriglyceridemia with pancreatitis. Journal of clinical lipidology. 2017;11(1):297-300. CR - Soares TS, Moraes-Souza RQ, Carneiro TB, Araujo-Silva VC, Schavinski AZ, Gratão TB, et al. Maternal-fetal outcomes of exercise applied in rats with mild hyperglycemia after embryonic implantation. Birth Defects Res. 2021;113(3):287-298. CR - Gligorijevic N, Stefanovic-Racic M, Kershaw EE. Medical management of hypertriglyceridemia in pancreatitis. Curr Opin Gastroenterol. 2023;39(5):421-427. UR - https://doi.org/10.55694/jamer.1400753 L1 - https://dergipark.org.tr/tr/download/article-file/3581033 ER -