@article{article_1404197, title={Galectin-3, an Indicator of Inflammation and Oxidation, is Linked with the Severity of Alzheimer’s Disease}, journal={Eskisehir Medical Journal}, volume={5}, pages={1–8}, year={2024}, author={Güner, Gürkan and Doğu, Burcu Balam and Kılıç, Mustafa Kemal and Kızılarslanoğlu, Muhammet Cemal and Varan, Hacer Doğan and Sağır, Aykut and Halil, Meltem and Akbıyık, Filiz and Cankurtaran, Mustafa}, keywords={Alzheimer Hastalığı, Biyobelirteç, Galektin-3, İnflamasyon, Oksidatif stres}, abstract={Introduction: Galectin-3 (Gal-3) is a multifunctional protein implicated in various biological processes, but the best-known role for galectin-3 is in acute and chronic inflammation. Inflammation plays an essential role in developing cognitive decline and dementia in old age. This study aims to investigate if galectin-3 can be an indicator of inflammation in Alzheimer’s Disease (AD) pathogenesis and a feasible biomarker of the disease. Methods: Forty-four Alzheimer’s Disease patients and 44 patients with normal cognitive function were enrolled in the study. Patients with known acute or chronic infections, chronic inflammatory diseases, cancer patients, and patients with rheumatological diseases affecting galectin-3 levels were excluded.
Results: Analysis revealed that the galectin-3 level of the AD group was higher than the control group. However, it was not statistically significant. According to the Global Deterioration Scale (GDS), the galectin-3 levels of patients in the moderately severe AD group (GDS stage 6) were significantly higher than the patients in the mild-moderate AD group (GDS stage 4-5). There was a significant weak negative correlation between galectin-3 levels and the Digit Span Forward (r = - 0.216, P = 0.043) and Backward (r = - 0.233, P = 0.029) tests. Conclusion: This study suggests that galectin-3 may play a role as an indicator of inflammation and oxidative stress in the pathogenesis of Alzheimer’s Disease. It appears to be associated with the severity of AD. However, further and more extensive prospective studies are needed to clarify the association.}, number={1}, publisher={Eskişehir Şehir Hastanesi}