TY  - JOUR
T1  - Determination of the Anti-inflammatory Cytokines in Smoking Individuals with Periodontitis
TT  - Sigara İçen Periodontitisli Bireylerde Anti-Inflamatuvar Sitokinlerin Belirlenmesi
AU  - Kasnak, Gökhan
AU  - Cantürk Ural, Emre
AU  - Karagülle, Liubov
AU  - Basegmez, Ayse Cansu
PY  - 2024
DA  - March
Y2  - 2024
JF  - Istanbul Kent University Journal of Health Sciences
JO  - IKUJHS
PB  - İstanbul Kent Üniversitesi
WT  - DergiPark
SN  - 2822-6615
SP  - 30
EP  - 38
VL  - 3
IS  - 1
LA  - en
AB  - Periodontitis, a chronic condition impacting the supportive tissues of teeth, manifests when the host's immune response becomes imbalanced with periodontal pathogens. Smoking emerges as a significant risk factor in both initiation and progression of periodontitis. During inflammatory process, a conspicuous upregulation of both proinflammatory and regulatory cytokines is unavoidable. Resolution of inflammation holds significance in the context of periodontitis, predominantly orchestrated by immune cells generating interleukin (IL)-4 and IL-10. Objective of this study was to evaluate the local and systemic involvement of IL-4 and -10 in individuals with severe periodontitis who are smokers. Fifty individuals with Stage III Grade C periodontitis were recruited, comprising both smokers and non-smokers, along with an additional fifty periodontally healthy individuals who were divided into smoking and non-smoking categories. Comprehensive periodontal indices were documented for all participants, and both venous blood and gingival crevicular fluid (GCF) samples were obtained for cytokine level analysis. Levels of IL-4 and -10 in GCF and serum samples were determined using a multiplex immunoassay. Statistical evaluation involved the use of Mann-Whitney U, Student-t, and Chi-square tests. In our investigation, all periodontal indices among individuals with periodontitis exhibited a statistically significant elevation compared to those of their healthy counterparts (p
KW  - Interleukin
KW  - Gingivalcrevicular fluid
KW  - Plasma
KW  - Serum
KW  - Periodontitis
KW  - Nicotine
N2  - Periodontitis, dişleri destekleyen dokuları etkileyen kronik bir hastalık olup periodontal patojenlere karşı konak bağışık yanıt dengesizliklerinde ortaya çıkar. Sigara, periodontitisin başlangıcında ve ilerlemesinde önemli bir risk faktörüdür. İnflamatuvar süreç sırasında, sitokinlerin belirgin bir şekilde artışı kaçınılmaz olup inflamasyonun çözünmesi periodontitiste önem taşımaktadır. İnflamasyonun çözülmesinde başlıca rol alan sitokinler interlökin (IL)-4 ve IL-10’dur. Bu çalışmanın amacı, şiddetli periodontitisli, sigara içen bireylerde IL-4 ve -10'un lokal ve sistemik katılımını değerlendirmekti. Bu amaç doğrultusunda, sigara içen ve içmeyen olarak ayrılmış Evre III Derece C periodontitisli 50 birey ile yine sigara içen ve içmeyen olarak ayrılmış periodontal olarak sağlıklı 50 birey çalışmaya dahil edildi. Periodontal indekslerin kaydını takiben IL-4 ve IL-10 düzeylerinin serumda ve diş eti oluğu sıvısındaki (DOS) analizi için tüm katılımcılardan venöz kan ve DOS örnekleri alındı. Sitokişn değerleri multipleks immunoassay yöntemi ile belirlendi. İstatistiksel değerlendirme Mann-Whitney U, Student-t ve Ki-kare testleri kullanılarak yapıldı. Araştırmamızda, periodontitisli bireyler arasında tüm periodontal indekslerin, sağlıklı bireylere oranla istatistiksel olarak önemli ölçüde yüksek olduğu bulundu (p
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UR  - https://dergipark.org.tr/tr/pub/ikujhs/issue//1425521
L1  - https://dergipark.org.tr/tr/download/article-file/3683532
ER  -