@article{article_1441204, title={Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line}, journal={Ege Tıp Dergisi}, volume={63}, pages={441–448}, year={2024}, DOI={10.19161/etd.1441204}, author={Kılıç, Kubilay Doğan and Kayabaş Avşar, Ayşenur and Özkanca, Cemre and Sal, Dila Hatun and Karabey, Fatih and Yılmaz, Zeynep Simge and Uyanıkgil, Yiğit}, keywords={Helianthemum germanicopolitanum, Kolon kanseri, HT-29 Hücre Hattı, Flavonoidler, Sitotoksisite}, abstract={Objective: The aim of this study was to investigate the cytotoxic effect of Helianthem germanicopolitanum Bornm., a rare endemic plant in Turkey, against colon cancer. Materials and Methods: After the extraction of Helianthemum germanicopolitanum Bornm. plant, the phytochemical profile of the plant was analyzed by High Performance Liquid Chromatography (HPLC). Cytotoxicity analysis on HT-29 human colon cancer cell line was performed by WST 1 assay. The results were compared with other studies on similar plant species in the literature. Results: H. germanicopolitanum plant contains various flavonoids and these flavonoids have cytotoxic effects on colorectal cancer cells. These cytotoxic effects provide anticarcinogenic effects by activating cell death pathways at certain concentrations. These findings provide an important insight into the therapeutic potential of the plant. Conclusion: Cytotoxicity studies of flavonoids in extracts obtained from extraction procedures on colorectal cancer cell lines show that flavonoids offer anticarcinogenic effects by activating cell death pathways at certain concentrations.}, number={3}, publisher={Ege Üniversitesi}