TY - JOUR T1 - Effect of Tocilizumab Treatment on Seroconversion in Hyperinflammation Secondary to Covid 19 TT - Covid 19'a Bağlı Hiperinflamasyonda Tocilizumab Tedavisinin Serokonversiyon Üzerine Etkisi AU - Arslan, Felemez AU - Karandere, Faruk AU - Yılmaz, Deniz AU - Şahin, Ezgi AU - Koçoğlu, Hakan AU - Işıksaçan, Nilgün PY - 2024 DA - April Y2 - 2024 DO - 10.30565/medalanya.1443962 JF - Acta Medica Alanya JO - Acta Med. Alanya PB - Alanya Alaaddin Keykubat Üniversitesi WT - DergiPark SN - 2587-0319 SP - 39 EP - 44 VL - 8 IS - 1 LA - en AB - Aim:During the ongoing COVID-19 pandemic, the management of hyperinflammation, a serious symptom that occurs secondary to the disease, has emerged as a major challenge. Tocilizumab, an immunosuppressive drug, offers a potential solution. However, it is extremely important to understand its effects on antibody formation after recovery from Covid-19. Therefore, our study aimed to investigate the effects of tocilizumab treatment on antibody production by measuring SARS-COV-2 spike total antibody levels at the third month post-infection in patients receiving this specific treatment.Materyal and Methods:Our study incorporated 48 patients diagnosed with Covid 19 who presented with hyperinflammation during hospitalization. These patients, admitted to our institution, were treated with tocilizumab and subsequently discharged. We meticulously determined the 3rd month SARS-COV-2 spike total antibody levels in these patients.Results:The participants of the study, characterized by a mean age of 52.5 ± 11.6 years, demonstrated positive SARS-COV-2 spike total antibody levels at 3 months, irrespective of age, gender, comorbidity, and length of hospital stay. The mean antibody levels in the patient population were quantified to be 223.58 ± 68.36 U/mL, with a range from 14.2 to 250 U/mL.Conclusion: Our findings reveal that all patients exhibited positive antibody levels at 3 months following tocilizumab treatment.This suggests that the administration of tocilizumab in the management of hyperinflammation secondary to Covid 19 does not adversely affect antibody formation, at least in the short term. This could have substantial implications for future treatment strategies. KW - COVID-19 KW - IL-6 KW - Hyperinflammation KW - Tocilizumab KW - Antibody N2 - Amaç:Devam eden COVID-19 pandemisi sürecinde, hastalığa ikincil olarak ortaya çıkan ciddi bir semptom olan hiperinflamasyonun yönetimi büyük bir meydan okuma olarak karşımıza çıkmıştır. İmmünsüpresif bir ilaç olan Tocilizumab, potansiyel bir çözüm sunmaktadır. Ancak, Covid-19'dan iyileşme sonrası antikor oluşumu üzerindeki etkilerini anlamak son derece önemlidir. Bu nedenle, çalışmamız bu spesifik tedaviyi alan hastalarda, enfeksiyon sonrası üçüncü ayda SARS-COV-2 spike toplam antikor seviyelerini ölçerek, tocilizumab tedavisinin antikor üretimi üzerindeki etkilerini araştırmayı amaçlamıştır. Yöntemler: Çalışmamız, hastaneye yatırıldıkları sırada hiperinflamasyon gösteren ve Covid-19 tanısı almış 48 hastayı içermektedir. Bu hastalar kurumumuza kabul edilmiş, tocilizumab ile tedavi edilmiş ve sonrasında taburcu edilmişlerdir. Bu hastaların 3. ay SARS-COV-2 spike toplam antikor seviyeleri titizlikle belirlenmiştir. Bulgular: Çalışmanın katılımcıları, ortalama yaşları 52,5 ± 11,6 olan, yaş, cinsiyet, komorbidite ve hastanede kalış süresi ne olursa olsun 3. ayda pozitif SARS-COV-2 spike toplam antikor seviyeleri göstermiştir. Hastaların ortalama antikor seviyeleri 223,58 ± 68,36 U/mL olarak ölçülmüş, aralık 14,2 ile 250 U/mL arasında değişmiştir. 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