@article{article_1444925, title={The relationship between gene-environment interaction in personalized nutrition, disease outcomes and ethical implications}, journal={ITU Journal of Food Science and Technology}, volume={3}, pages={1–10}, year={2025}, author={İnanlar, Batuhan and Kemer, Aslı Pınar and Şahin Yeşilçubuk, Neşe and Demirel, Birsen}, keywords={nutrigenomik, etik, kişiselleştirilmiş beslenme}, abstract={The increasing recognition of the pivotal role of healthy nutrition has prompted a profound exploration into the intricate interplay between genes and dietary patterns. Following the discovery of the human genome map, the conventional understanding of diet’s role expanded beyond mere sustenance and adequate nutrition. In recent years, personalized nutrition has emerged as a dynamic and multidimensional field of inquiry, encompassing various facets, including the analysis of dietary patterns, the identification of disease determinants and underlying causes, the intricate interrelationship between genetic factors and one’s current health status, legislative considerations, and the promising landscape of innovations poised to revolutionize the field. Personalized nutrition, rooted in genotype-based approaches, seeks to prevent chronic diseases, and enhance overall wellness. This innovative field encompasses two main pillars: nutrigenetics and nutrigenomics. Nutrigenomics further enables the identification of genes influencing physiological responses to diet and the subtle genetic variations, or polymorphisms, that impact crucial nutritional outcomes, while also shedding light on the influence of environmental factors on gene expression. Moreover, it aims to understand gene and diet interactions at the cellular and molecular level and to create nutritional strategies specific to the individual’s genome. New findings in nutrition research using genomic techniques will help nutrition researchers and nutritionists to make more personalized recommendations; therefore, it is thought that compliance with dietary recommendations may increase when supported by genomic-based information. The inclusion of personalized nutrition in our health system may help us prevent the onset and progression of diseases. This comprehensive review delves into the multifaceted realm of personalized nutrition, elucidating its potential to reshape future studies and guide the development of tailored nutrition plans. Beyond its current scope, personalized nutrition promises to guide in a paradigm shift in how we approach health and well-being, making it an essential cornerstone in the evolution of healthcare and lifestyle choices. As this evolving situation is explored in more depth, synergies between genes and nutrition will enable improvements in the approach to health and well-being.}, number={1}, publisher={İstanbul Teknik Üniversitesi}