TY  - JOUR
T1  - CURRENT OVERVIEW OF CLINICAL AND RADIOLOGICAL FINDINGS ASSOCIATED WITH CEREBRAL AMYLOID ANGIOPATHY
AU  - Kızıldağ, Betül
AU  - Yurttutan, Nursel
PY  - 2024
DA  - May
Y2  - 2024
DO  - 10.51972/tfsd.1448781
JF  - Turkish Journal of Science and Health
JO  - TFSD
PB  - Ümit Muhammet KOÇYİĞİT
WT  - DergiPark
SN  - 2717-7173
SP  - 104
EP  - 113
VL  - 5
IS  - 2
LA  - en
AB  - Cerebral amyloid angipopathy (CAA),  the second most common cause of spontaneous acute intracerebral hemorrhage after hypertension in the elderly population is characterized by brain parenchymal damage secondary to hemorrhage and ischemia caused by the accumulation of Aβ protein in the walls of small arteries and arterioles. Advanced age is the most significant risk factor for CAA. While the definitive diagnosis requires histopathological examination through autopsy/biopsy, the probable or possible diagnosis of CAA is based on clinical features as well as characteristic neuroimaging findings.With the increasing elderly population and the growing prevalence of succesibility-weighted magnetic resonance imaging sequences in routine,  it becomes imperative to have a thorough understanding of the imaging spectrum associated with CAA. Early diagnosis is extremely critical in patients with CAA who have not yet developed intracranial hemorrhage. Furthermore, patients with CAA may present clinically transient focal neurological episodes or cognitive impairment, which can be mistaken for transient ischemic attacks caused by convexity subarachnoid hemorrhage. Additionally, before initiating newly introduced anti-amyloid monoclonal antibody drugs in Alzheimer's disease, it is necessary to exclude signs of CAA. Moreover, the anticipated side effects of these drugs often manifest imaging abnormalities resembling inflammation or bleeding associated with CAA, necessitating familiarity with the imaging findings of CAA. In this review, the pathophysiology, clinical manifestations, and radiological findings of sporadic CAA will be detailed.
KW  - cerebral amyloid angiopathy
KW  - suscebility weighted imaging
KW  - cerebral bleeding
CR  - Biffi, A., Halpin, A., Towfighi, A., Gilson, A., Busl, K., Rost, N., ... & Viswanathan, A. (2010). Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology, 75(8), 693-698. DOI: 10.1212/WNL.0b013e3181eee40f
CR  - Biffi, A., & Greenberg, S. M. (2011). Cerebral amyloid angiopathy: a systematic review. Journal of clinical neurology (Seoul, Korea), 7(1), 1. DOI: 10.3988/jcn.2011.7.1.1
CR  - Brashear, H. R., Ketter, N., Bogert, J., Di, J., Salloway, S. P., & Sperling, R. (2018). Clinical evaluation of amyloid-related imaging abnormalities in bapineuzumab phase III studies. Journal of Alzheimer's Disease, 66(4), 1409-1424. DOI: 10.3233/JAD-180675
CR  - Charidimou, A., Gang, Q., & Werring, D. J. (2012a). Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. Journal of Neurology, Neurosurgery & Psychiatry, 83(2), 124-137. DOI: 10.1136/jnnp-2011-301308
CR  - Charidimou, A., Peeters, A., Fox, Z., Gregoire, S. M., Vandermeeren, Y., Laloux, P., ... & Werring, D. J. (2012b). Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre magnetic resonance imaging cohort study and meta-analysis. Stroke, 43(9), 2324-2330. DOI: 10.1161/STROKEAHA.112.657759
CR  - Charidimou, A., Jaunmuktane, Z., Baron, J. C., Burnell, M., Varlet, P., Peeters, A., ... & Werring, D. J. (2014). White matter perivascular spaces: an MRI marker in pathology-proven cerebral amyloid angiopathy?. Neurology, 82(1), 57-62. DOI: 10.1212/01.wnl.0000438225.02729.04
CR  - Charidimou, A., Martinez-Ramirez, S., Shoamanesh, A., Oliveira-Filho, J., Frosch, M., Vashkevich, A., ... & Viswanathan, A. (2015a). Cerebral amyloid angiopathy with and without hemorrhage: evidence for different disease phenotypes. Neurology, 84(12), 1206-1212. DOI: 10.1212/WNL.0000000000001398
CR  - Charidimou, A., Linn, J., Vernooij, M. W., Opherk, C., Akoudad, S., Baron, J. C., ... & Werring, D. J. (2015b). Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. Brain, 138(8), 2126-2139. DOI: 10.1093/brain/awv162
CR  - Charidimou, A., Boulouis, G., Frosch, M. P., Baron, J. C., Pasi, M., Albucher, J. F., ... & Greenberg, S. M. (2022). The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study. The Lancet Neurology, 21(8), 714-725. DOI: 10.1016/S1474-4422(22)00208-3
CR  - Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996). Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV. Neurology, 46(6), 1592-1596.doi:10.1212/wnl.46.6.1592.
CR  - Eng, J. A., Frosch, M. P., Choi, K., Rebeck, G. W., & Greenberg, S. M. (2004). Clinical manifestations of cerebral amyloid angiopathy–related inflammation. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 55(2), 250-256. doi: 10.1002/ana.10810.
CR  - Greenberg, S. M., & Vonsattel, J. P. G. (1997). Diagnosis of cerebral amyloid angiopathy: sensitivity and specificity of cortical biopsy. Stroke, 28(7), 1418-1422.  doi: 10.1161/01.str.28.7.1418.
CR  - Greenberg, C. H., Frosch, M. P., Goldstein, J. N., Rosand, J., & Greenberg, S. M. (2012). Modeling intracerebral hemorrhage growth and response to anticoagulation. PLoS One, 7(10), e48458. doi: 10.1371/journal.pone.0048458.
CR  - Greenberg, S. M., & Charidimou, A. (2018). Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria. Stroke, 49(2), 491-497. DOI: 10.1161/STROKEAHA.117.016990
CR  - Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020). Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways. Nature Reviews Neurology, 16(1), 30-42. DOI: 10.1038/s41582-019-0281-2
CR  - Hawkes, C. A., Jayakody, N., Johnston, D. A., Bechmann, I., & Carare, R. O. (2014). Failure of perivascular drainage of β‐amyloid in cerebral amyloid angiopathy. Brain Pathology, 24(4), 396-403. DOI: 10.1111/bpa.12159
CR  - Kimberly W.T., Gilson A, Rost N.S. et al., (2019). Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy. Neurology. 72(14), 1230-5. DOI: 10.1212/01.wnl.0000345666.83318.03.
CR  - Koo, H. W., Jo, K. I., Yeon, J. Y., Kim, J. S., & Hong, S. C. (2016). Clinical features of high-degree centrum semiovale-perivascular spaces in cerebral amyloid angiopathy. Journal of the neurological sciences, 367, 89-94. DOI: 10.1016/j.jns.2016.05.040
CR  - Lee, J. M., & Markus, H. S. (2006). Does the white matter matter in Alzheimer disease and cerebral amyloid angiopathy?. Neurology, 66(1), 6-7. . DOI: 10.1212/01.wnl.0000196863.43951.44
CR  - Maia, L. F., Mackenzie, I. R., & Feldman, H. H. (2007). Clinical phenotypes of cerebral amyloid angiopathy. Journal of the neurological sciences, 257(1-2), 23-30. DOI: 10.1016/j.jns.2007.01.054
CR  - Martinez-Ramirez, S., Pontes-Neto, O. M., Dumas, A. P., Auriel, E., Halpin, A., Quimby, M., ... & Viswanathan, A. (2013). Topography of dilated perivascular spaces in subjects from a memory clinic cohort. Neurology, 80(17), 1551-1556. DOI: 10.1212/WNL.0b013e31828f1876
CR  - Morrone, C. D., Liu, M., Black, S. E., & McLaurin, J. (2015). Interaction between therapeutic interventions for Alzheimer’s disease and physiological Aβ clearance mechanisms. Frontiers in Aging Neuroscience, 7, 64. DOI: 10.3389/fnagi.2015.00064
CR  - Poels, M. M., Ikram, M. A., van der Lugt, A., Hofman, A., Niessen, W. J., Krestin, G. P., ... & Vernooij, M. W. (2012). Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology, 78(5), 326-333. DOI: 10.1212/WNL.0b013e3182452928
CR  - Revesz, T., Holton, J. L., Lashley, T., Plant, G., Rostagno, A., Ghiso, J., & Frangione, B. (2002). Sporadic and familial cerebral amyloid angiopathies. Brain pathology, 12(3), 343-357. doi: 10.1111/j.1750-3639.2002.tb00449.x.
CR  - Schweser, F., Deistung, A., Lehr, B. W., & Reichenbach, J. R. (2010). Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping. Medical physics, 37(10), 5165-5178. DOI: 10.1118/1.3481505
CR  - Sharma, R., Dearaugo, S., Infeld, B., O'Sullivan, R., & Gerraty, R. P. (2018). Cerebral amyloid angiopathy: review of clinico‐radiological features and mimics. Journal of Medical Imaging and Radiation Oncology, 62(4), 451-463. DOI: 10.1111/1754-9485.12726
CR  - Smith, E. E., Charidimou, A., Ayata, C., Werring, D. J., & Greenberg, S. M. (2021). Cerebral amyloid angiopathy–related transient focal neurologic episodes. Neurology, 97(5), 231-238. DOI: 10.1212/WNL.0000000000012234
CR  - Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., ... & De Leon, M. J. (2015). Clearance systems in the brain—implications for Alzheimer disease. Nature reviews neurology, 11(8), 457-470. DOI: 10.1038/nrneurol.2015.119
CR  - Vinters, H. V. (1987). Cerebral amyloid angiopathy. A critical review. Stroke, 18(2), 311-324. https://doi.org/10.1161/01.STR.18.2.311
CR  - Viswanathan, A., & Greenberg, S. M. (2011). Cerebral amyloid angiopathy in the elderly. Annals of neurology, 70(6), 871-880. DOI: 10.1002/ana.22516
CR  - Withington, C. G., & Turner, R. S. (2022). Amyloid-related imaging abnormalities with anti-amyloid antibodies for the treatment of dementia due to Alzheimer's disease. Frontiers in Neurology, 13, 862369. DOI: 10.3389/fneur.2022.862369
UR  - https://doi.org/10.51972/tfsd.1448781
L1  - https://dergipark.org.tr/tr/download/article-file/3779888
ER  -