TY  - JOUR
T1  - Clinicopathological Correlation of Invasive Histological Features in Incidentally Detected Appendiceal Neuroendocrine Tumors (aNETs)
TT  - Tesadüfen Tespit Edilen Appendisal Nöroendokrin Tümörlerde (aNET) İnvaziv Histolojik Özelliklerin Klinikopatolojik Korelasyonu
AU  - Sayar, Ceren
AU  - Umudum, Haldun
AU  - Bedir, Recep
AU  - Turan, Zafer
PY  - 2024
DA  - December
Y2  - 2024
DO  - 10.29058/mjwbs.1449624
JF  - Medical Journal of Western Black Sea
JO  - Med J West Black Sea
PB  - Zonguldak Bülent Ecevit Üniversitesi
WT  - DergiPark
SN  - 2822-4302
SP  - 291
EP  - 298
VL  - 8
IS  - 3
LA  - en
AB  - Aim: Appendiceal Neuroendocrine Tumors (aNETs) are rare and mostly detected incidentally patients operated on acute appendicitis. Theseare indolent tumors and mostly benign, however they carry risk of metastasis. This study aims to identify invasive histological features ofaNET cases, that are correlated with aggressive behavior other than stage and grading parameters.Material and Methods: This retrospective study includes patient demographics, surgical margin status and pathological features of tumors.ANETs showing adenocarcinoma features, goblet cell features, and mixed features were not included in our study.Results: The mean age of cases with tumors is 41years (11-61 years). The mean tumor diameter was found to be 6.8 mm. Most of tumorswere located in the distal appendix (55.5%). All of the tumors show invasive features. Four cases showed invasion to submucosa (pT₁),four cases to muscularis propria (pT₁), eight cases to subserosa (pT₃), and four cases to mesoappendix (pT₃). Follow-up information wasavailable for only one case with Grade-2 features and MAI, no additional surgical treatment was required, and he has survived at 3-yearfollow-up with no metastasis.Conclusion: Even if it is grade 1stage 1 tumors, may exhibit invasive features with a risk of metastasis. Although LVI and PNI are notincluded in ANET staging, they are important factors affecting the course of the disease. The literature lacks consensus on the advisabilityof performing completion right hemicolectomy in patients exhibiting invasive histological features. We believe it prudent to maintain regularfollow-up intervals for these individuals
KW  - Appendix
KW  - neuroendocrine tumors
KW  - invasive histological features
N2  - Amaç: Apendiks Nöroendokrin Tümörleri (aNET'ler) nadir görülen ve çoğunlukla akut apandisit nedeniyle ameliyat edilen hastalarda tesadüfensaptanan tümörlerdir. Bunlar yavaş ilerleyen ve çoğunlukla iyi huylu tümörlerdir ancak metastaz riski taşırlar. Bu çalışma, ANET vakalarınınevre ve derecelendirme parametreleri dışındaki agresif davranışlarla ilişkili invazif histolojik özelliklerini tanımlamayı amaçlamaktadır.Gereç ve Yöntemler: Bu retrospektif çalışma hasta demografik özelliklerini, cerrahi sınır durumunu ve tümörlerin patolojik özellikleriniiçermektedir. Adenokarsinom özellikleri, goblet hücresi özellikleri ve karma özellikler gösteren ANET'ler çalışmamıza dahil edilmedi.Bulgular: Tümörlü olguların yaş ortalaması 41'dir (11-61). Ortalama tümör çapı 6,8 mm olarak bulundu. Tümörlerin çoğu distal apendiksyerleşimlidir (55.5%). Tümörlerin tamamı invaziv özellik göstermektedir. Dört vakada submukozaya (pT₁), dört vakada muskularis propriaya(pT₁), sekiz vakada subserozaya (pT₃) ve dört vakada mezoapendikse (pT₃) invazyon görüldü. Sadece 2.derece özellikleri ve MAI'si olan birolgu için takip bilgisi mevcuttu, ek cerrahi tedaviye gerek duyulmadı ve 3 yıllık takipte metastaz olmaksızın hayatta kaldı.Sonuç: Birinci derece ve evre-1 tümörler olsa bile metastaz riski taşıyan invaziv özellikler gösterebilir. LVI ve PNI ANET evrelemesindeyer almasa da hastalığın seyrini etkileyen önemli faktörlerdir. Literatürde invaziv histolojik özellikler sergileyen hastalarda tamamlayıcı sağhemikolektomi yapılmasının tavsiye edilebilirliği konusunda fikir birliği yoktur. Bu bireyler için düzenli takip aralıklarının sürdürülmesininakıllıca olacağına inanıyoruz.
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UR  - https://doi.org/10.29058/mjwbs.1449624
L1  - https://dergipark.org.tr/tr/download/article-file/3782728
ER  -